G
Gene M. Shearer
Researcher at National Institutes of Health
Publications - 366
Citations - 30334
Gene M. Shearer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 83, co-authored 366 publications receiving 29889 citations. Previous affiliations of Gene M. Shearer include Salk Institute for Biological Studies & Rush University Medical Center.
Papers
More filters
Journal ArticleDOI
Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
Robert C. Gallo,Syed Zaki Salahuddin,Mikulas Popovic,Gene M. Shearer,Mark H. Kaplan,Barton F. Haynes,Thomas J. Palker,Robert R. Redfield,James M. Oleske,Bijan Safai,Gilbert C. White,Paul Foster,Phillip D. Markham +12 more
TL;DR: Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV).
Journal ArticleDOI
A TH1→TH2 switch is a critical step in the etiology of HIV infection
Mario Clerici,Gene M. Shearer +1 more
TL;DR: This viewpoint proposes that an imbalance in the TH1-type and TH2-type responses contributes to the immune dysregulation associated with HIV infection, and that resistance to HIV infection and/or progression to AIDS is dependent on a TH1-->TH2 dominance.
Journal ArticleDOI
T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years
R. Michael Blaese,Kenneth W. Culver,A. Dusty Miller,Charles S. Carter,Thomas A. Fleisher,Mario Clerici,Gene M. Shearer,Lauren A. Chang,Yawen Chiang,Paul Tolstoshev,Jay J. Greenblatt,Steven A. Rosenberg,Harvey G. Klein,Melvin Berger,Craig A. Mullen,W. Jay Ramsey,Linda M. Muul,Richard A. Morgan,W. French Anderson +18 more
TL;DR: In this article, a clinical trial was started using retroviral-mediated transfer of the ADA gene into the T cells of two children with severe combined immunodeficiency (ADA-SCID).
Journal ArticleDOI
Modulation of Inflammation and Immunity by Cyclic AMP
Henry R. Bourne,Lawrence M. Lichtenstein,Kenneth L. Melmon,C S Henney,Yacob Weinstein,Gene M. Shearer +5 more
Journal ArticleDOI
Administration of 3'-azido-3'-deoxythymidine, an inhibitor of htlv-iii/lav replication, to patients with aids or aids-related complex
Robert Yarchoan,Kent J. Weinhold,H. Kim Lyerly,Edward P. Gelmann,Robert M. Blum,Gene M. Shearer,Hiroaki Mitsuya,Jerry M. Collins,Charles E. Myers,Raymond W. Klecker,Phillip D. Markham,David T. Durack,S. Nusinoff Lehrman,David W. Barry,Margaret A. Fischl,Robert C. Gallo,Dani P. Bolognesi,Samuel Broder +17 more
TL;DR: 4 dose regimens of 3'-azido-3'-deoxythymidine (AZT), a thymidine analogue with potent anti-viral activity against HTLV-III in vitro, were examined in 19 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC).