Geoff deRosenroll

TL;DR: It is demonstrated that direction selectivity in downstream ganglion cells remains remarkably unaffected when starburst dendrites are rendered non-directional, using a novel strategy combining a conditional GABAA α2 receptor knockout mouse with optogenetics.

TL;DR: A combination of paired patch-clamp recordings, serial EM, and large-scale multi-electrode array recordings are used to show that a single high-sensitivity source of glutamate is processed differentially by starbursts via AMPA receptors and DSGCs via NMDA receptors, which reveals a space-efficient synaptic circuit model for direction computations, in which "silent"NMDA receptors play critical roles.

TL;DR: In this article, the ultrastructural features of cholinergic connections between direction-selective starburst amacrine cells and downstream ganglion cells were characterized using electrophysiology and two-photon acetylcholine (ACh) imaging.

TL;DR: This work combines two-photon calcium imaging with genetic, pharmacological, and single-cell ablation methods to examine the extent to which inhibition ‘vetoes’ excitation at the level of individual dendrites of direction-selective ganglion cells and demonstrates that inhibition shapes direction selectivity independently within small dendritic segments with remarkable accuracy.