G
Geoffrey L. Greene
Researcher at University of Chicago
Publications - 267
Citations - 28897
Geoffrey L. Greene is an academic researcher from University of Chicago. The author has contributed to research in topics: Estrogen receptor & Receptor. The author has an hindex of 71, co-authored 237 publications receiving 27622 citations. Previous affiliations of Geoffrey L. Greene include University of California, San Francisco & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Molecular basis of agonism and antagonism in the oestrogen receptor.
Andrzej M. Brzozowski,Ashley C. W. Pike,Zbigniew Dauter,Roderick E. Hubbard,Tomas Bonn,Owe Engström,Lars Öhman,Geoffrey L. Greene,Jan-Åke Gustafsson,Mats Carlquist +9 more
TL;DR: The crystal structures of the LBD of ER in complex with the endogenous oestrogen, 17β-oestradiol, and the selective antagonist raloxifene provide a molecular basis for the distinctive pharmacophore of the ER and its catholic binding properties.
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The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
Andrew K. Shiau,Danielle Barstad,Paula M. Loria,Lin Cheng,Peter J. Kushner,David A. Agard,Geoffrey L. Greene +6 more
TL;DR: Crystal structures of the human estrogen receptor alpha (hER alpha) ligand-binding domain (LBD) and the OHT-LBD complex reveal the two distinct mechanisms by which structural features of OHT promote this "autoinhibitory" helix 12 conformation.
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Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells.
TL;DR: The development of an immunocytochemical procedure suitable for localizing oestrophilin directly in frozen tissue sections or cells from human and several non-human sources is reported.
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Sequence and expression of human estrogen receptor complementary DNA
TL;DR: A complementary DNA clone containing the entire translated portion of the messenger RNA for the estrogen receptor from MCF-7 human breast cancer cells was sequenced and then expressed in Chinese hamster ovary cells to give a functional protein, which suggests that steroid receptor genes and the avian erythroblastosis viral oncogene are derived from a common primordial gene.
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Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells.
TL;DR: The existence of a putative membrane estrogen receptor (ER) has been supported by studies accomplished over the past 20 yr as mentioned in this paper, however, the origin and functions of this receptor are not well defined.