G
Georg H. Waetzig
Researcher at University of Kiel
Publications - 60
Citations - 5625
Georg H. Waetzig is an academic researcher from University of Kiel. The author has contributed to research in topics: Glycoprotein 130 & Receptor. The author has an hindex of 32, co-authored 59 publications receiving 4778 citations. Previous affiliations of Georg H. Waetzig include Plon & Leiden University.
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Journal ArticleDOI
Genetic variation in DLG5 is associated with inflammatory bowel disease
Monika Stoll,Brit Corneliussen,Christine M. Costello,Georg H. Waetzig,Bjorn Mellgard,W. Andreas Koch,Philip Rosenstiel,Mario Albrecht,Peter J. P. Croucher,Dirk Seegert,Susanna Nikolaus,Jochen Hampe,Thomas Lengauer,Stefan Pierrou,Ulrich R. Foelsch,Christopher G. Mathew,Maria Lagerström-Fermér,Stefan Schreiber +17 more
TL;DR: A significant difference in association of the 113A DLG5 variant with Crohn disease is found in affected individuals carrying the risk- associated CARD15 alleles versus those carrying non-risk-associated CARD 15 alleles, suggestive of a complex pattern of gene-gene interaction betweenDLG5 and CARD15, reflecting the complex nature of polygenic diseases.
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Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection
Stephan J. Ott,Georg H. Waetzig,Ateequr Rehman,Jacqueline Moltzau-Anderson,Jacqueline Moltzau-Anderson,Richa Bharti,Juris A. Grasis,Liam Cassidy,Andreas Tholey,Helmut Fickenscher,Dirk Seegert,Philip Rosenstiel,Stefan Schreiber +12 more
TL;DR: A preliminary investigation of 5 patients with CDI shows that transfer of sterile filtrates from donor stool (FFT), rather than fecal microbiota, can be sufficient to restore normal stool habits and eliminate symptoms.
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TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells ☆ ☆☆ ★ ★★ ♢
Philip Rosenstiel,Massimo Fantini,Massimo Fantini,Karen Bräutigam,T Kühbacher,Georg H. Waetzig,Dirk Seegert,Stefan Schreiber +7 more
TL;DR: TNF-α(/IFN-γ) treatment up-regulates the expression of the NOD2 gene in intestinal epithelial cells and subsequently increases their LPS susceptibility.
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p38 Mitogen-Activated Protein Kinase Is Activated and Linked to TNF-α Signaling in Inflammatory Bowel Disease
TL;DR: P38α signaling is involved in the pathophysiology of IBD, and ELISA screening of the supernatants of Crohn’s disease mucosal biopsy cultures showed that incubation with the p38 inhibitor SB 203580 significantly reduced secretion of TNF-α.
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The IL-6/sIL-6R complex as a novel target for therapeutic approaches.
TL;DR: Preclinical animal disease models have provided strong evidence that specific blockade of IL-6-regulated signalling pathways represents a promising approach for the therapy of these diseases.