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Georg Halder

Researcher at Katholieke Universiteit Leuven

Publications -  86
Citations -  19276

Georg Halder is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Hippo signaling pathway & Hippo signaling. The author has an hindex of 54, co-authored 82 publications receiving 17074 citations. Previous affiliations of Georg Halder include University of Texas MD Anderson Cancer Center & University of Basel.

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Bin Zhao, +20 more
- 01 Nov 2007 - 
TL;DR: It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition.
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Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila

Georg Halder, +2 more
- 24 Mar 1995 - 
TL;DR: By targeted expression of the ey complementary DNA in various imaginal disc primordia of Drosophila, ectopic eye structures were induced on the wings, the legs, and on the antennae and support the proposition that ey is the master control gene for eye morphogenesis.
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Hippo signaling: growth control and beyond

Georg Halder, +1 more
- 01 Jan 2011 - 
TL;DR: Recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development are reviewed and exciting new insights are provided into the elusive mechanisms that regulate organ growth and regeneration.
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The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Randy L. Johnson, +1 more
- 01 Jan 2014 - 
TL;DR: The regulation of the Hippo signalling pathway, its functions in normal homeostasis and disease, and recent progress in the identification of small-molecule pathway modulators are reviewed.
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Transduction of mechanical and cytoskeletal cues by YAP and TAZ

Georg Halder, +2 more
- 01 Sep 2012 - 
TL;DR: Cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP and TAZ in vertebrates and Yorkie in flies, which may explain how mechanical signals can direct normal and pathological cell behaviour.