G
George Cachianes
Researcher at Genentech
Publications - 17
Citations - 8947
George Cachianes is an academic researcher from Genentech. The author has contributed to research in topics: Plasmid & Vascular endothelial growth factor A. The author has an hindex of 13, co-authored 17 publications receiving 8771 citations.
Papers
More filters
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Growth hormone receptor and serum binding protein: purification, cloning and expression
David W. Leung,Steven A. Spencer,George Cachianes,R. Glenn Hammonds,Carol Collins,William J. Henzel,Ross Barnard,Michael J. Waters,William I. Wood +8 more
TL;DR: The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.
Journal ArticleDOI
The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA
TL;DR: Alternative splicing of VEGF RNA can produce four polypeptides with strikingly different secretion patterns, which suggests multiple physiological roles for this family of proteins.
Journal ArticleDOI
Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein
William I. Wood,George Cachianes,William J. Henzel,Genine A. Winslow,Steven A. Spencer,Renate Hellmiss,Janet L. Martin,Robert C. Baxter +7 more
TL;DR: The deduced protein sequence of BP-53 has 33% amino acid identity including conservation of all 18 cysteine residues with the recently cloned BP-28, a smaller human IGF-binding protein identified in amniotic fluid and also secreted by the cell line HEP G2.