G
George Davey Smith
Researcher at University of Bristol
Publications - 2646
Citations - 294406
George Davey Smith is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Mendelian randomization. The author has an hindex of 224, co-authored 2540 publications receiving 248373 citations. Previous affiliations of George Davey Smith include Keele University & Western Infirmary.
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Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Wouter van Rheenen,Rick A.A. van der Spek,Mark K Bakker,Joke J.F.A. van Vugt,Paul J. Hop,Ramona A. J. Zwamborn,Niek de Klein,Harm-Jan Westra,Olivier B. Bakker,Patrick Deelen,Patrick Deelen,Gemma Shireby,Eilis Hannon,Matthieu Moisse,Denis Baird,Restuadi Restuadi,Egor Dolzhenko,Annelot M. Dekker,Klara Gawor,Henk-Jan Westeneng,Gijs H.P. Tazelaar,Kristel R. van Eijk,Maarten Kooyman,Ross P. Byrne,Mark A. Doherty,Mark Heverin,Ahmad Al Khleifat,Alfredo Iacoangeli,Alfredo Iacoangeli,Aleksey Shatunov,Nicola Ticozzi,Johnathan Cooper-Knock,Bradley N. Smith,Marta Gromicho,Siddharthan Chandran,Suvankar Pal,Karen E. Morrison,Pamela J. Shaw,John Hardy,Richard W. Orrell,Michael Sendtner,Thomas Meyer,Nazli Basak,Anneke J. van der Kooi,Antonia Ratti,Isabella Fogh,Cinzia Gellera,Giuseppe Lauria Pinter,Stefania Corti,Cristina Cereda,Daisy Sproviero,Sandra D'Alfonso,Gianni Sorarù,Gabriele Siciliano,Massimiliano Filosto,Alessandro Padovani,Adriano Chiò,Andrea Calvo,Cristina Moglia,Maura Brunetti,Antonio Canosa,Maurizio Grassano,Ettore Beghi,Elisabetta Pupillo,Giancarlo Logroscino,Beatrice Nefussy,Alma Osmanovic,Angelica Nordin,Yossef Lerner,Yossef Lerner,Michal Zabari,Michal Zabari,Marc Gotkine,Marc Gotkine,Robert H. Baloh,Shaughn Bell,Patrick Vourc'h,Philippe Corcia,Philippe Couratier,Stéphanie Millecamps,Vincent Meininger,François Salachas,Jesus S. Mora Pardina,Abdelilah Assialioui,Ricardo Rojas-García,Patrick A. Dion,Jay P. Ross,Jay P. Ross,Albert C. Ludolph,Jochen H. Weishaupt,David A. Brenner,Axel Freischmidt,Axel Freischmidt,Gilbert Bensimon,Alexis Brice,Alexandra Durr,Christine Payan,Safa Saker-Delye,Nicholas W. Wood,Simon Topp,Rosa Rademakers,Lukas Tittmann,Wolfgang Lieb,Andre Franke,Stephan Ripke,Stephan Ripke,Stephan Ripke,Alice Braun,Julia Kraft,David C. Whiteman,Catherine M. Olsen,André G. Uitterlinden,Albert Hofman,Marcella Rietschel,Sven Cichon,Markus M. Nöthen,Philippe Amouyel,Bryan J. Traynor,Bryan J. Traynor,Adrew B. Singleton,Miguel Mitne Neto,Ruben J. Cauchi,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Martina Wiedau-Pazos,Catherine Lomen-Hoerth,Vivianna M. Van Deerlin,Julian Grosskreutz,A. Rödiger,Nayana Gaur,Alexander Jörk,Tabea Barthel,Erik Theele,Benjamin Ilse,Beatrice Stubendorff,Otto W. Witte,Robert Steinbach,Christian A. Hübner,Caroline Graff,Lev Brylev,Vera Fominykh,Vera Demeshonok,Anastasia Ataulina,Boris Rogelj,Blaž Koritnik,Janez Zidar,Metka Ravnik-Glavač,Damjan Glavač,Zorica Stevic,Vivian E. Drory,Mònica Povedano,Ian P. Blair,Matthew C. Kiernan,Beben Benyamin,Beben Benyamin,Robert D. Henderson,Robert D. Henderson,Sarah Furlong,Susan Mathers,Pamela A. McCombe,Pamela A. McCombe,Merrilee Needham,Merrilee Needham,Merrilee Needham,Shyuan T. Ngo,Garth A. Nicholson,Roger Pamphlett,Dominic B. Rowe,Frederik J. Steyn,Frederik J. Steyn,Kelly L. Williams,Karen A. Mather,Karen A. Mather,Perminder S. Sachdev,Anjali K. Henders,Leanne Wallace,Mamede de Carvalho,Susana Pinto,Susanne Petri,Markus Weber,Guy A. Rouleau,Vincenzo Silani,Charles Curtis,Gerome Breen,Gerome Breen,Jonathan D. Glass,Robert H. Brown,John Landers,Christopher Shaw,Peter M. Andersen,Ewout J N Groen,Michael A. van Es,R. Jeroen Pasterkamp,Dongsheng Fan,Fleur C. Garton,Allan F. McRae,George Davey Smith,Tom R. Gaunt,Michael A. Eberle,Jonathan Mill,Russell L. McLaughlin,Orla Hardiman,Kevin P. Kenna,Naomi R. Wray,Ellen A. Tsai,Heiko Runz,Lude Franke,Ammar Al-Chalabi,Ammar Al-Chalabi,Philip Van Damme,Leonard H. van den Berg,Jan H. Veldink +212 more
TL;DR: All ALS associated signals combined reveal a role for perturbations in vesicle mediated transport and autophagy, and provide evidence for cell-autonomous disease initiation in glutamatergic neurons.
Journal ArticleDOI
The Association of C-Reactive Protein and CRP Genotype with Coronary Heart Disease: Findings from Five Studies with 4,610 Cases amongst 18,637 Participants
Debbie A Lawlor,Roger M. Harbord,Nic Timpson,Gordon D.O. Lowe,Ann Rumley,Tom R. Gaunt,I. A. Baker,John Yarnell,Mika Kivimäki,Meena Kumari,Paul Norman,Konrad Jamrozik,Graeme J. Hankey,Osvaldo P. Almeida,L. Flicker,Nicole M. Warrington,Michael Marmot,Yoav Ben-Shlomo,Lyle J. Palmer,Lyle J. Palmer,Ian N. M. Day,Shah Ebrahim,George Davey Smith +22 more
TL;DR: The findings do not support a causal association between circulating CRP and CHD risk, but very large, extended, genetic association studies would be required to rule this out.
Journal ArticleDOI
ACTN3 genotype, athletic status, and life course physical capability: meta-analysis of the published literature and findings from nine studies
Tamuno Alfred,Yoav Ben-Shlomo,Rachel Cooper,Rebecca Hardy,Cyrus Cooper,Cyrus Cooper,Ian J. Deary,David Gunnell,Sarah E. Harris,Meena Kumari,Richard M. Martin,Colin Neil Moran,Yannis P. Pitsiladis,Susan M. Ring,Avan Aihie Sayer,Avan Aihie Sayer,George Davey Smith,John M. Starr,Diana Kuh,Ian N. M. Day +19 more
TL;DR: Evidence from the published literature is found to support the hypothesis that in Europeans the RR genotype is more common among sprint/power athletes compared with their controls and there is currently no evidence that the X allele is advantageous to endurance athleticism.
Journal ArticleDOI
Association of body mass index measured in childhood, adolescence, and young adulthood with risk of ischemic heart disease and stroke: findings from 3 historical cohort studies
Debbie A Lawlor,Richard M. Martin,David Gunnell,Bruna Galobardes,Shah B. Ebrahim,Jat Sandhu,Yoav Ben-Shlomo,Peter McCarron,George Davey Smith +8 more
TL;DR: Results do not provide strong evidence that being overweight or obese in childhood is associated with future cardiovascular disease risk, and no association was found between overweight or obesity and stroke risk.
Journal ArticleDOI
Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study
Ashley Budu-Aggrey,Ben Michael Brumpton,Jess Tyrrell,Jess Tyrrell,Sarah H Watkins,Ellen Heilmann Modalsli,Carlos Celis-Morales,Lyn D. Ferguson,Gunnhild Åberge Vie,Tom Palmer,Lars G. Fritsche,Mari Løset,Jonas B. Nielsen,Wei Zhou,Lam C. Tsoi,Andrew R. Wood,Samuel E. Jones,Robin N Beaumont,Marit Saunes,Pål Richard Romundstad,Stefan Siebert,Iain B. McInnes,James T. Elder,James T. Elder,George Davey Smith,Timothy M. Frayling,Bjørn Olav Åsvold,Sara J. Brown,Sara J. Brown,Naveed Sattar,Lavinia Paternoster +30 more
TL;DR: Evidence that higher BMI leads to a higher risk of psoriasis is provided, which supports the prioritization of therapies and lifestyle interventions aimed at controlling weight for the prevention or treatment of this common skin disease.