George Davey Smith

TL;DR: The results suggest that the ischaemia-reperfusion response associated with conventional aneurysm surgery may be largely negated by endovascular techniques, which may have significant consequences as the generation of oxygen free radicals and cytokines have been implicated in the development of systemic organ failure following aortic surgery.

TL;DR: This paper performed two genome-wide association studies (GWASs) of circulating amounts of C-reactive protein (CRP) by using data from 88 studies comprising 204,402 European individuals.

TL;DR: In this paper, the causal role of SHBG for type 2 diabetes is investigated using Mendelian randomization and the results showed that higher SHBG was associated with a more favorable cardiometabolic risk profile, including associations with lipoprotein subclasses, fatty acid composition, amino acids, ketone bodies and inflammation-linked glycoproteins.

TL;DR: The aim here was to assess the contribution of common genetic variation to a adjusted version of that phenotype which appropriately accounts for covariation in height in children.

TL;DR: The arguments are illustrated using real examples (stroke and educational attainment) and a simulation study is used to illustrate when correction might be ineffective for avoiding biases and how problems can be avoided.