G
George Davey Smith
Researcher at University of Bristol
Publications - 2646
Citations - 294406
George Davey Smith is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Mendelian randomization. The author has an hindex of 224, co-authored 2540 publications receiving 248373 citations. Previous affiliations of George Davey Smith include Keele University & Western Infirmary.
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Adult height and cause-specific mortality: a large prospective study of South Korean men.
TL;DR: There was little evidence of associations for coronary heart disease or overall cancer mortality, but stomach cancer showed a weak inverse association that was attenuated after adjustment and strong inverse associations with death from stroke, respiratory disease, and external causes were observed.
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Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges.
TL;DR: It is suggested that GWAS, to date, have generally not focused on phenotypes that directly relate to the progression of disease and thus speak to disease treatment, and this has yet to be realized at a level reflecting expectation.
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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Jie Zheng,Valeriia Haberland,Denis Baird,Venexia M Walker,Philip C Haycock,Mark R. Hurle,Alex Gutteridge,Pau Erola,Yi Liu,Shan Luo,Shan Luo,Jamie Robinson,Tom G. Richardson,James R Staley,James R Staley,Benjamin Elsworth,Stephen Burgess,Benjamin B. Sun,John Danesh,Heiko Runz,Joseph C. Maranville,Hannah M. Martin,James Yarmolinsky,Charles Laurin,Michael V. Holmes,Jimmy Z. Liu,Karol Estrada,Rita Santos,Linda McCarthy,Dawn M. Waterworth,Matthew R. Nelson,George Davey Smith,Adam S. Butterworth,Gibran Hemani,Robert A. Scott,Tom R. Gaunt +35 more
TL;DR: Evaluation of data from historic drug development programs showed that target-indication pairs with MR and colocalization support were more likely to be approved, evidencing the value of this approach in identifying and prioritizing potential therapeutic targets.
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Early results of autologous chondrocyte implantation in the talus.
JP Whittaker,George Davey Smith,Nilesh Makwana,Sally Roberts,P.E. Harrison,Patrick Laing,James B. Richardson +6 more
TL;DR: Ten patients with an osteochondral lesion of the talus who underwent ACI using cartilage taken from the knee and were prospectively reviewed with a mean follow-up of 23 months report good results despite donor-site morbidity.
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Is there an intrauterine influence on obesity? Evidence from parent–child associations in the Avon Longitudinal Study of Parents and Children (ALSPAC)
TL;DR: Comparison of mother–offspring and father-offspring associations for BMI suggests that intergenerational acceleration mechanisms do not make an important contribution to levels of childhood BMI within the population.