G
George Davey Smith
Researcher at University of Bristol
Publications - 2646
Citations - 294406
George Davey Smith is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Mendelian randomization. The author has an hindex of 224, co-authored 2540 publications receiving 248373 citations. Previous affiliations of George Davey Smith include Keele University & Western Infirmary.
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Journal ArticleDOI
Prenatal and early life influences on epigenetic age in children: a study of mother–offspring pairs from two cohort studies
Andrew J Simpkin,Gibran Hemani,Matthew Suderman,Tom R. Gaunt,Oliver Lyttleton,Wendy L. McArdle,Susan M. Ring,Gemma C Sharp,Kate Tilling,Steve Horvath,Sonja Kunze,Annette Peters,Melanie Waldenberger,Cavin K. Ward-Caviness,Ellen A. Nohr,Thorkild I. A. Sørensen,Caroline L Relton,George Davey Smith +17 more
TL;DR: In children, epigenetic AA measures are associated with several clinically relevant variables, and early life exposures appear to be associated with changes in AA during adolescence, and further research into epigenetic aging is required to better understand of aging.
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The Role of Obesity, Type 2 Diabetes, and Metabolic Factors in Pancreatic Cancer: A Mendelian Randomization Study
Robert Carreras-Torres,Mattias Johansson,Valerie Gaborieau,Philip C Haycock,Kaitlin H Wade,Caroline L Relton,Richard M. Martin,George Davey Smith,Paul Brennan +8 more
TL;DR: A causal role of BMI and fasting insulin in pancreatic cancer etiology is suggested, and no evidence of a causal relationship was observed for type 2 diabetes, nor for dyslipidemia.
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How accurately are height, weight and leg length reported by the elderly, and how closely are they related to measurements recorded in childhood?
David Gunnell,Lee Berney,Paula Holland,Maria J Maynard,David Blane,Stephen Frankel,George Davey Smith +6 more
TL;DR: Self-reported height was overestimated and body mass index (BMI), based on reported height and weight, underestimated, and associations between childhood and adult height, leg length and BMI measured in old age indicate that avoidance of adiposity may be as important in childhood as in adulthood.
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Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
Debbie A Lawlor,Nicholas J. Timpson,Nicholas J. Timpson,Roger M. Harbord,Sam D Leary,Andy R Ness,Mark I. McCarthy,Mark I. McCarthy,Timothy M. Frayling,Andrew T. Hattersley,George Davey Smith +10 more
TL;DR: Neither the parental comparisons nor the use of FTO genotype as an instrumental variable, suggest that greater maternal BMI during offspring development has a marked effect on offspring fat mass at age 9–11 y, which is unlikely to have driven the recent obesity epidemic.
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Genetic Markers of Adult Obesity Risk Are Associated with Greater Early Infancy Weight Gain and Growth
Cathy E. Elks,Ruth J. F. Loos,Stephen J. Sharp,Claudia Langenberg,Susan M. Ring,Nicholas J. Timpson,Andy R Ness,George Davey Smith,David B. Dunger,Nicholas J. Wareham,Ken K. Ong +10 more
TL;DR: Ken Ong and colleagues genotyped children from the ALSPAC birth cohort and showed an association between greater early infancy gains in weight and length and genetic markers for adult obesity risk.