G
George J. Poiani
Researcher at Rutgers University
Publications - 11
Citations - 682
George J. Poiani is an academic researcher from Rutgers University. The author has contributed to research in topics: Pulmonary hypertension & Hypoxia (medical). The author has an hindex of 8, co-authored 11 publications receiving 513 citations. Previous affiliations of George J. Poiani include Robert Wood Johnson University Hospital & United States Department of Veterans Affairs.
Papers
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Journal ArticleDOI
An Update on Current Therapeutic Drugs Treating COVID-19.
Renyi Wu,Lujing Wang,Hsiao-Chen Dina Kuo,Ahmad Shannar,Rebecca Peter,Pochung Jordan Chou,Shanyi Li,Rasika Hudlikar,Xia Liu,Xia Liu,Zhigang Liu,George J. Poiani,George J. Poiani,Louis F. Amorosa,Luigi Brunetti,Luigi Brunetti,Ah-Ng Tony Kong +16 more
TL;DR: It is hoped that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2.
Journal ArticleDOI
Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19.
Luigi Brunetti,Luigi Brunetti,Oumou Diawara,Andrew Tsai,Bonnie L. Firestein,Ronald Nahass,George J. Poiani,George J. Poiani,Naomi Schlesinger +8 more
TL;DR: Patients receiving colchicine were approximately five times more likely to be discharged than those receiving standard of care at the end of the 28 day follow-up, and these observations warrant further investigation in large controlled clinical trials.
Journal ArticleDOI
Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers.
David Cheng,Wenji Li,Wenji Li,Lujing Wang,Tiffany Lin,George J. Poiani,George J. Poiani,Andrew Wassef,Rasika Hudlikar,Patricia Ondar,Luigi Brunetti,Luigi Brunetti,Ah-Ng Tony Kong +12 more
TL;DR: The results show that the bioavailability of the parent curcumin compound is low, and oral administration ofCurcumin can still deliver detectable levels of curCumin glucuronide metabolite, and antioxidant and epigenetic effects which could contribute to the overall health beneficial effects of Curcumin are elicited.
Patent
Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor
TL;DR: In this article, a method for treating pulmonary hypertension and other diseases involving a defect in collagen metabolism, by administration of an effective amount of a liposome encapsulated copolymer conjugate antifibrotic composition, is disclosed.
Journal ArticleDOI
Recombinant human relaxin reduces hypoxic pulmonary hypertension in the rat.
Carol A. Tozzi,George J. Poiani,Nansie A. McHugh,Michael P. Sharkarjian,Beverly H. Grove,Chrishan S. Samuel,Elaine N. Unemori,David J. Riley +7 more
TL;DR: It is concluded that rhRlx inhibits the early fibroproliferative response in hypoxic pulmonary hypertension and the mechanism may be due in part to suppression of collagen synthesis.