Author
George L. Ellman
Bio: George L. Ellman is an academic researcher from Dow Chemical Company. The author has contributed to research in topics: Reactivity (chemistry) & Chemistry. The author has an hindex of 5, co-authored 6 publications receiving 22790 citations.
Topics: Reactivity (chemistry), Chemistry, Sensitization, Vasopressin, Reprint
Papers
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TL;DR: A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid] has been synthesized and shown to be useful for determination of sulfhydryl groups.
23,232 citations
TL;DR: A study of the specificity of the reaction indicates that it occurs only with the S − group (actual or potential, as in thiourea), and heavy-metal ions interfere with the reaction by irreversibly bonding any S − ions.
1,053 citations
TL;DR: The most sensitive chemical method for determining epinephrine in solution is the reaction with ethylenediamine, which yields a number of products, several of which are fluorescent, which can be used for quantitative measurement.
Abstract: THE most sensitive chemical method for determining epinephrine in solution is the reaction with ethylenediamine. The reaction yields a number of products, several of which are fluorescent. These substances can be used for quantitative measurement. Nor-epinephrine produces a fluorescence of different colour so that mixtures of the two compounds can be determined by the selection of appropriate filters in measuring the fluorescent light1.
18 citations
TL;DR: Analysis of this phenomenon indicates that it is due to sensitization of the vascular bed by the amines to a pituitary hormone released by the various stimuli used, probably equivalent to vasopressin.
Abstract: A prolonged and frequently extreme pressor response subsequent to the usual pressor response to asphyxia, nicotine injection or carotid occlusion has been observed in dogs, cats and monkeys treated with certain pressor aminies. Analysis of this phenomenon indicates that it is due to sensitization of the vascular bed, largely that of the intestine, by the amines to a pituitary hormone released by the various stimuli used. This hormone is probably equivalent to vasopressin.
12 citations
Cited by
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TL;DR: A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid] has been synthesized and shown to be useful for determination of sulfhydryl groups.
23,232 citations
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
23,015 citations
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
16,953 citations
TL;DR: A simple spectrophotometric method for the routine concomitant determination of sulfhydryl groups in PB- SH, NP-SH, and T-SH fractions in various tissues is reported.
7,141 citations
TL;DR: The use of the foregoing analytical method in the determination of total and oxidized glutathione contents of rat blood, kidney, and liver gave values in good agreement with those obtained by previous investigators.
5,900 citations