G
George M. Burslem
Researcher at University of Pennsylvania
Publications - 6
Citations - 35
George M. Burslem is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Intracellular signal transduction & Kinase activity. The author has an hindex of 2, co-authored 6 publications receiving 10 citations.
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Journal ArticleDOI
The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation.
Michael Grasso,Gavin J. Bond,Gavin J. Bond,Ye-Jin Kim,Stefanie D. Boyd,Maria Matson Dzebo,Sebastian Valenzuela,Tiffany Tsang,Natalie A. Schibrowsky,Katherine B. Alwan,Ninian J. Blackburn,George M. Burslem,Pernilla Wittung-Stafshede,Duane D. Winkler,Ronen Marmorstein,Donita C. Brady +15 more
TL;DR: In this paper, the authors used surface plasmon resonance and proximity-dependent biotin ligase studies to investigate the role of the chaperone CCS in MEK1 and MEK2.
Journal ArticleDOI
Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres.
Adam I. Green,George M. Burslem +1 more
TL;DR: In this article, the suitability of some commercially available screening collections in the context of epigenetic drug discovery, with a particular focus on lysine post-translational modifications, was analyzed.
Journal ArticleDOI
Advances and Opportunities in Epigenetic Chemical Biology
TL;DR: The key targets for modulation and recent methods developed to enact such modulation are highlighted and the wealth of protein synthesis approaches to yield histones and nucleosomes bearing epigenetic modifications is addressed.
Journal ArticleDOI
The role of chemical biology in the fight against SARS-CoV-2.
TL;DR: In this paper, the importance of science at the chemistry/biology interface to both understand and combat the SARS-CoV-2 pandemic is described, and a review is presented.
Posted ContentDOI
Structural and molecular determinants of CCS-mediated copper activation of MEK1/2
Michael Grasso,Gavin J. Bond,Ye-Jin Kim,Katherine B. Alwan,Stefanie D. Boyd,Maria Matson Dzebo,Sebastian Valenzuela,Tiffany Tsang,Natalie A. Schibrowsky,Megan L. Matthews,George M. Burslem,Pernilla Wittung-Stafshede,Duane D. Winkler,Ninian J. Blackburn,Ronen Marmorstein,Donita C. Brady +15 more
TL;DR: Atomic and molecular level data provide the first mechanistic insights of Cu kinase signaling and could be exploited for the development of novel MEK1/2 inhibitors that either target the Cu structural interface or blunt dedicated Cu delivery mechanisms via CCS.