G
George M. Whitesides
Researcher at Harvard University
Publications - 1754
Citations - 287794
George M. Whitesides is an academic researcher from Harvard University. The author has contributed to research in topics: Monolayer & Self-assembled monolayer. The author has an hindex of 240, co-authored 1739 publications receiving 269833 citations. Previous affiliations of George M. Whitesides include University of California, Davis & University of Texas at Austin.
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Combinatorial computational method gives new picomolar ligands for a known enzyme
Bartosz A. Grzybowski,Alexey V. Ishchenko,Chu-Young Kim,George Topalov,Robert G. Chapman,David W. Christianson,George M. Whitesides,Eugene I. Shakhnovich +7 more
TL;DR: The designed R isomer is the best-known inhibitor of human carbonic anhydrase II and computational predictions concerning the binding affinities and the binding modes were correct for both isomers.
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Using magnetic levitation to distinguish atomic-level differences in chemical composition of polymers, and to monitor chemical reactions on solid supports.
TL;DR: A density-based method that uses magnetic levitation for monitoring solid-supported reactions and for distinguishing differences in chemical composition of polymers is described, particularly useful for monitoring the kinetics of reactions occurring on polymer beads.
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Neuraminidase-resistant hemagglutination inhibitors: acrylamide copolymers containing a C-glycoside of N-acetylneuraminic acid.
TL;DR: Copolymers consisting of a polyacrylamide backbone with side chains terminated in C-glycosidic analogs of N-acetylneuraminic acid are synthesized by free radical copolymerization of alpha-2-C-[3-[[2-(N-acryloylamino)ethyl]thio]propyl]-N- acetylneursic acid (5) with acrylamides.
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Mechanism of formation of Grignard reagents. Kinetics of reaction of alkyl halides in diethyl ether with magnesium
Harold R. Rogers,Craig L. Hill,Yuzo Fujiwara,Randall J. Rogers,H. Lee Mitchell,George M. Whitesides +5 more
TL;DR: The rate of reaction of organic halides with magnesium is proportional to organic halide concentration and magne- sium surface area as mentioned in this paper, and the two most plausible limiting rate-determining steps are halogen atom abstraction and electron transfer.
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Optical waveguiding using thermal gradients across homogeneous liquids in microfluidic channels
TL;DR: In this article, a liquid-core liquid-cladding (L2) optical waveguide composed of a thermal gradient across a compositionally homogeneous liquid flowing in a microfluidic channel at low Reynolds number is described.