G
George P. Tegos
Researcher at Harvard University
Publications - 93
Citations - 8575
George P. Tegos is an academic researcher from Harvard University. The author has contributed to research in topics: Antimicrobial & Efflux. The author has an hindex of 45, co-authored 88 publications receiving 7121 citations. Previous affiliations of George P. Tegos include University of Tulsa & Northeastern University.
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Journal ArticleDOI
Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy and beyond
Fatma Vatansever,Wanessa C.M.A. de Melo,Wanessa C.M.A. de Melo,Pinar Avci,Pinar Avci,Daniela Vecchio,Magesh Sadasivam,Magesh Sadasivam,Asheesh Gupta,Asheesh Gupta,Rakkiyappan Chandran,Rakkiyappan Chandran,Mahdi Karimi,Mahdi Karimi,Nivaldo Antonio Parizotto,Rui Yin,Rui Yin,George P. Tegos,Michael R. Hamblin,Michael R. Hamblin +19 more
TL;DR: Antioxidant defenses against ROS in microbial cells and the use of ROS by antimicrobial host defense systems are covered and reactive nitrogen species and related therapeutics, such as acidified nitrite and nitric oxide-releasing nanoparticles are covered.
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Multidrug Pump Inhibitors Uncover Remarkable Activity of Plant Antimicrobials
TL;DR: The results suggest that plants might have developed means of delivering their antimicrobials into bacterial cells and suggest that plant antimicroBials might be developed into effective, broad-spectrum antibiotics in combination with inhibitors of MDRs.
Journal ArticleDOI
Photoantimicrobials-are we afraid of the light?
Mark Wainwright,Tim Maisch,Santi Nonell,Kristjan Plaetzer,Adelaide Almeida,George P. Tegos,Michael R. Hamblin,Michael R. Hamblin +7 more
TL;DR: This Personal View raises awareness of the novel photoantimicrobial technologies that offer a viable alternative to conventional drugs in many relevant application fields, and could thus slow the pace of resistance development.
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The value of antimicrobial peptides in the age of resistance
Maria Magana,Muthuirulan Pushpanathan,Ana L. Santos,Leon G. Leanse,Michael Fernandez,Anastasios Ioannidis,Marc A. Giulianotti,Yiorgos Apidianakis,Steven B. Bradfute,Andrew L. Ferguson,Artem Cherkasov,Mohamed N. Seleem,Clemencia Pinilla,Cesar de la Fuente-Nunez,Themis Lazaridis,Themis Lazaridis,Tianhong Dai,Richard A. Houghten,Robert E. W. Hancock,George P. Tegos +19 more
TL;DR: The benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens are identified, advances in the deployment of novel promising antimacterial peptides are highlighted, and the needs and priorities in designing focused development strategies taking into account the most advanced tools available are underlined.
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Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond?
Tianhong Dai,Asheesh Gupta,Asheesh Gupta,Clinton K. Murray,Mark S. Vrahas,George P. Tegos,George P. Tegos,Michael R. Hamblin,Michael R. Hamblin +8 more
TL;DR: Under certain wavelengths and radiant exposures, blue light may cause cell dysfunction by the photo-excitation of blue light sensitizing chromophores, including flavins and cytochromes, within mitochondria or/and peroxisomes.