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Author

Georges Jeminet

Bio: Georges Jeminet is an academic researcher from Blaise Pascal University. The author has contributed to research in topics: Undecane & Ionophore. The author has an hindex of 18, co-authored 67 publications receiving 1224 citations. Previous affiliations of Georges Jeminet include Centre national de la recherche scientifique.
Topics: Undecane, Ionophore, Monensin, Nigericin, Calcimycin


Papers
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TL;DR: Using molecular mechanics, it is found that hydroxyl, ketone, and lactone groups are involved in the formation of both hydrogen bonds and van der Waals interactions between aflatoxins B1, deoxynivalenol and patulin, and beta-D-glucans.

166 citations

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TL;DR: Cooperativity and the three-dimensional structure of beta-D-glucans indicate that weak noncovalent bonds are involved in the complex-forming mechanisms associated with zearalenone, which is more of an adsorption type than a binding type.

148 citations

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TL;DR: This work focused on the role of various beta-d-glucan types in the efficacy of zearalenone adsorption by yeast cell wall and sought to elucidate some of the advertisersorption mechanisms.
Abstract: The isolated cell wall of Saccharomyces cerevisiae has some capacity to adsorb zearalenone (affinity near 30%) and reduce the bioavailability of toxins in the digestive tract. The adsorption process was quantified in vitro, and the data obtained when plotted with Hill's equation indicated a cooperative process. The model showed that the adsorption capacity was related to the yeast cell wall composition. This work focused on the role of various beta-d-glucan types in the efficacy of zearalenone adsorption by yeast cell wall and sought to elucidate some of the adsorption mechanisms. Zearalenone was mixed at 37 degrees C with a constant quantity of alkali-soluble or alkali-insoluble beta-d-glucans isolated from yeast cell walls, and the amount of adsorbed zearalenone was measured. Given that the alkali solubility of beta-d-glucans is a determining factor for their three-dimensional conformation and that the alkali-insoluble fraction had a greater affinity (up to 50%) than the alkali-soluble fraction ( approximately 16%), it was concluded that the three-dimensional structure strongly influences the adsorption process. The alkali insolubility of beta-d-glucans led to the formation of single and/or triple helices, which have been identified as the most favorable structures for zearalenone adsorption efficacy. The beta(1,3)-d-glucan and beta(1,6)-d-glucan compositions of the two alkali-extracted fractions and their involvement in the adsorption process are discussed.

107 citations

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TL;DR: This study used powerful devices to elucidate the spatial conformation and molecular sites of interaction between ZEN and beta-D-glucans and to propose highly probable complexes of zearalenone with laminarin fragment.

92 citations

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TL;DR: In this article, the association of monovalent cations with polyethyleneglycol ethers has been investigated and the 1:1 association constants KA have been obtained in methyl alcohol at 25 °C.
Abstract: We report data concerning the association of monovalent cations with some polyethyleneglycol ethers that we have prepared.1:1 association constants KA have been obtained in methyl alcohol at 25 °C ...

64 citations


Cited by
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Journal ArticleDOI
TL;DR: Since no susceptibility breakpoints are available for most of the antibiotics discussed, an alternative approach to the interpretation of MICs is presented and some pharmacokinetic data and information on the influence of these products on the intestinal flora are presented.
Abstract: There are not many data available on antibiotics used solely in animals and almost exclusively for growth promotion. These products include bambermycin, avilamycin, efrotomycin, and the ionophore antibiotics (monensin, salinomycin, narasin, and lasalocid). Information is also scarce for bacitracin used only marginally in human and veterinary medicine and for streptogramin antibiotics. The mechanisms of action of and resistance mechanisms against these antibiotics are described. Special emphasis is given to the prevalence of resistance among gram-positive bacteria isolated from animals and humans. Since no susceptibility breakpoints are available for most of the antibiotics discussed, an alternative approach to the interpretation of MICs is presented. Also, some pharmacokinetic data and information on the influence of these products on the intestinal flora are presented.

637 citations

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TL;DR: This review discusses the available literature on the mycotoxin binding by S. cerevisiae and lactic acid bacteria and the scope of developments in the field and describes the different potential decontaminating microorganisms.
Abstract: Mycotoxins represent one of the important classes of naturally occurring toxicants in food, posing considerable health risk. Biological decontamination of mycotoxins using microorganisms is one of the well-known strategies for the management of mycotoxins in foods and feeds. Among the different potential decontaminating microorganisms, Saccharomyces cerevisiae and lactic acid bacteria represent unique groups, which are widely used in food fermentation and preservation. This review discusses the available literature on the mycotoxin binding by S. cerevisiae and lactic acid bacteria and the scope of developments in the field.

397 citations

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TL;DR: The objectives of this paper are to review the most important findings on effects of ADYs in the rumen, to describe identified modes of action, and to provide thoughts for further strain selection and applications in ruminant nutrition.

395 citations

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TL;DR: Any prevention strategy for fungal and mycotoxin contamination must be carried out at an integrative level all along the food production chain.

319 citations