G
Georgios I. Papachristou
Researcher at The Ohio State University Wexner Medical Center
Publications - 273
Citations - 8667
Georgios I. Papachristou is an academic researcher from The Ohio State University Wexner Medical Center. The author has contributed to research in topics: Acute pancreatitis & Pancreatitis. The author has an hindex of 45, co-authored 233 publications receiving 6816 citations. Previous affiliations of Georgios I. Papachristou include Northwestern University & Veterans Health Administration.
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Journal ArticleDOI
Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis
Georgios I. Papachristou,Venkata Muddana,Dhiraj Yadav,Michael O’Connell,Michael K. Sanders,Adam Slivka,David C. Whitcomb +6 more
TL;DR: It is confirmed that the BISAP score is an accurate means for risk stratification in patients with AP and simple scoring systems may have reached their maximal utility and novel models are needed to further improve predictive accuracy.
Journal ArticleDOI
Lipotoxicity Causes Multisystem Organ Failure and Exacerbates Acute Pancreatitis in Obesity
Sarah Navina,Chathur Acharya,James P. DeLany,Lidiya Orlichenko,Catherine J. Baty,Sruti Shiva,Chandra Durgampudi,Jenny M. Karlsson,Kenneth K.W. Lee,Kyongtae T. Bae,Alessandro Furlan,Jaideep Behari,Shiguang Liu,Teresa McHale,Larry Nichols,Georgios I. Papachristou,Dhiraj Yadav,Vijay P. Singh +17 more
TL;DR: Evidence is gathered that therapeutic approaches that target unsaturated fatty acid–mediated lipotoxicity may reduce adverse outcomes in obese patients with critical illnesses such as severe acute pancreatitis, and that inhibiting lipolysis with the drug orlistat can prevent the pancreatic-associated rise in serum uns saturated fatty acids and reduce damage to the lung and kidney.
Journal ArticleDOI
Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis.
Rawad Mounzer,Christopher J. Langmead,Bechien U. Wu,Anna C. Evans,Faraz Bishehsari,Venkata Muddana,Vikesh K. Singh,Adam Slivka,David C. Whitcomb,Dhiraj Yadav,Peter A. Banks,Georgios I. Papachristou,Georgios I. Papachristou +12 more
TL;DR: The existing scoring systems seem to have reached their maximal efficacy in predicting persistent organ failure in acute pancreatitis, and 12 predictive rules that combined these scores to optimize predictive accuracy are developed.
Journal ArticleDOI
New insights into acute pancreatitis
TL;DR: A summary of recent advances in acute pancreatitis with a special emphasis on pathophysiological mechanisms and clinical management of the disorder is provided.
Journal ArticleDOI
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
David C. Whitcomb,Jessica LaRusch,Alyssa M. Krasinskas,Lambertus Klei,Jill P. Smith,Randall E. Brand,John P. Neoptolemos,Markus M. Lerch,Matt Tector,Bimaljit S. Sandhu,Nalini M. Guda,Lidiya Orlichenko,Samer Alkaade,Stephen T. Amann,Michelle A. Anderson,John Baillie,Peter A. Banks,Darwin L. Conwell,Gregory A. Cote,Peter B. Cotton,James A. DiSario,Lindsay A. Farrer,Chris E. Forsmark,Marianne Johnstone,Timothy B. Gardner,Andres Gelrud,William Greenhalf,Jonathan L. Haines,Douglas J. Hartman,Robert A. Hawes,Christopher Lawrence,Michele D. Lewis,Julia Mayerle,Richard Mayeux,Nadine M. Melhem,Mary E. Money,Thiruvengadam Muniraj,Georgios I. Papachristou,Margaret A. Pericak-Vance,Joseph Romagnuolo,Gerard D. Schellenberg,Stuart Sherman,Peter Simon,Vijay P. Singh,Adam Slivka,Donna B. Stolz,Robert Sutton,Frank Ulrich Weiss,C. Mel Wilcox,Narcis O. Zarnescu,Stephen R. Wisniewski,Michael R. O'Connell,Michelle L. Kienholz,Kathryn Roeder,M. Michael Barmada,Dhiraj Yadav,Bernie Devlin,Marilyn S. Albert,Roger L. Albin,Roger L. Albin,Liana G. Apostolova,Steven E. Arnold,Clinton T. Baldwin,Robert Barber,Lisa L. Barnes,Thomas G. Beach,Gary W. Beecham,Duane Beekly,David A. Bennett,Eileen H. Bigio,Thomas D. Bird,Deborah Blacker,Adam L. Boxer,James R. Burke,Joseph D. Buxbaum,Nigel J. Cairns,Laura B. Cantwell,Chuanhai Cao,Regina M. Carney,Steven L. Carroll,Helena C. Chui,David G. Clark,David H. Cribbs,Elizabeth Crocco,Carlos Cruchaga,Charles DeCarli,F. Yesim Demirci,Malcolm B. Dick,Dennis W. Dickson,Ranjan Duara,Nilufer Ertekin-Taner,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Tatiana Foroud,Matthew P. Frosch,Douglas Galasko,Mary Ganguli,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Sid Gilman,Jonathan D. Glass,Alison Goate,Neill R. Graff-Radford,Robert C. Green,John H. Growdon,Hakon Hakonarson,Kara L. Hamilton-Nelson,Ronald L. Hamilton,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Christine M. Hulette,Bradley T. Hyman,Gregory A. Jicha,Lee-Way Jin,Gyungah Jun,M. Ilyas Kamboh,Anna Karydas,Jeffrey Kaye,Jeffrey Kaye,Ronald C. Kim,Edward H. Koo,Neil W. Kowall,Joel H. Kramer,Patricia L. Kramer,Walter A. Kukul,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Chiao-Feng Lin,Andrew P. Lieberman,Oscar L. Lopez,Kathryn L. Lunetta,Constantine G. Lyketsos,Wendy J. Mack,Daniel C. Marson,Eden R. Martin,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Thomas J. Montine,John C. Morris,Jill R. Murrel,Adam C. Naj,Adam C. Naj,John M Olichney,Joseph E. Parisi,Elaine R. Peskind,Ronald C. Petersen,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Eric M. Reiman,Barry Reisberg,Christiane Reitz,John M. Ringman,Erik D. Roberson,Howard J. Rosen,Roger N. Rosenberg,Mary Sano,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Amanda Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Rudolph E. Tanzi,John Q. Trojanowski,Juan C. Troncoso,Juan C. Troncoso,Debby W. Tsuang,Otto Valladares,Vivianna M. Van Deerlin,Linda J. Van Eldik,Badri N. Vardarajan,Harry V. Vinters,Jean Paul Vonsatte,Li-San Wang,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Randall L. Woltjer,Clinton B. Wright,Steven G. Younkin,Chang En Yu,Lei Yu +201 more
TL;DR: Two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 are reported and could partially explain the high frequency of alcohol-related pancreatitis in men.