G
Geqing Wang
Researcher at La Trobe University
Publications - 18
Citations - 263
Geqing Wang is an academic researcher from La Trobe University. The author has contributed to research in topics: DsbA & Oxidative folding. The author has an hindex of 9, co-authored 16 publications receiving 185 citations. Previous affiliations of Geqing Wang include Monash University & University of Adelaide.
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Journal ArticleDOI
Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens
Makrina Totsika,Dimitrios Vagenas,Jason J. Paxman,Geqing Wang,Rabeb Dhouib,Pooja Sharma,Jennifer L. Martin,Martin J. Scanlon,Begoña Heras +8 more
TL;DR: This work demonstrates that DsbA inhibitors can be developed to target diverse homologues found in bacteria, and identifies highly conserved residues surrounding the active site for 20 diverse bacterial DSBA enzymes, which could be exploited in developing inhibitors with a broad spectrum of activity.
Journal ArticleDOI
Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR.
Xiaopeng Ge,Christopher A. MacRaild,Shane M. Devine,Cael Debono,Geqing Wang,Peter J. Scammells,Martin J. Scanlon,Robin F. Anders,Michael Foley,Raymond S. Norton +9 more
TL;DR: An efficient means of probing ligand-induced conformational change in the malaria drug target AMA1 using 19F NMR is established, and an increase in flexibility in this loop caused by the native ligand, as inferred from, but not directly observed in, crystal structures is demonstrated.
Journal ArticleDOI
The Fragment-Based Development of a Benzofuran Hit as a New Class ofEscherichia coliDsbA Inhibitors.
TL;DR: The potential to develop benzofuran fragments into a novel class of EcDsbA inhibitors is suggested, which is critical for the correct folding of virulence factors in many pathogenic Gram-negative bacteria.
Journal ArticleDOI
Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules
Jason J. Paxman,Alvin W. Lo,Matthew J. Sullivan,Santosh Panjikar,Santosh Panjikar,Michael J. Kuiper,Andrew E. Whitten,Geqing Wang,Chi Hao Luan,Danilo Gomes Moriel,Lendl Tan,Kate M. Peters,Minh-Duy Phan,Christine L. Gee,Glen C. Ulett,Mark A. Schembri,Begoña Heras +16 more
TL;DR: The crystal structure of autotransporter UpaB is presented and evidence for distinct binding sites for glycosaminoglycans and host fibronectin is shown, suggesting that this domain can interact with host macromolecules.
Journal ArticleDOI
Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data
Biswaranjan Mohanty,Martin Williams,Bradley C. Doak,M. Vazirani,O.V. Ilyichova,Geqing Wang,Wolfgang Bermel,Jamie S. Simpson,David K. Chalmers,Glenn F. King,Mehdi Mobli,Martin J. Scanlon +11 more
TL;DR: It is demonstrated that using a single sample, which can be prepared without the use of expensive precursors, it is possible to generate high-resolution data rapidly and obtain the resonance assignments of Ile, Leu, Val, Ala and Thr methyl groups using triple resonance scalar correlation data.