G
Ger T. Rijkers
Researcher at University Medical Center Utrecht
Publications - 71
Citations - 7542
Ger T. Rijkers is an academic researcher from University Medical Center Utrecht. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 36, co-authored 71 publications receiving 7153 citations. Previous affiliations of Ger T. Rijkers include Boston Children's Hospital & University College Roosevelt.
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Intestinal microbiota in human health and disease: the impact of probiotics
TL;DR: The effects of probiotic consumption on the intestinal microbiota are addressed, as well as the development of tailor-made probiotics designed for specific aberrations that are associated with microbial dysbiosis.
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Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells.
TL;DR: A multiplex cytokine assay to detect different cytokines simultaneously in culture supernatant of human peripheral blood mononuclear cells stimulated with antigen and with mitogen was developed and proved to be a powerful tool in the quantitation of cytokines.
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Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome
Sander M. Houten,W. Kuis,Marinus Duran,T. J. de Koning,A. Van Royen-Kerkhof,G. J. Romeijn,J. Frenkel,Lambertus Dorland,M. M. J. De Barse,W. A. R. Huijbers,Ger T. Rijkers,Hans R. Waterham,Ronald J.A. Wanders,B. T. Poll-The +13 more
TL;DR: In this paper, the authors analyzed urine of several patients and discovered increased concentrations of mevalonic acid during severe episodes of fever, but not between crises, indicating a protein-destabilizing effect of the mutations.
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CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis
Ismé M. de Kleer,Lucy R. Wedderburn,Leonie S. Taams,Alka Patel,Hemlata Varsani,Mark Klein,Wilco de Jager,Gisela Pugayung,Francesca Giannoni,Ger T. Rijkers,Salvatore Albani,Wietse Kuis,Berent J. Prakken +12 more
TL;DR: A markedly higher expression of CTLA-4, glucocorticoid-induced TNFR, and HLA-DR on SF CD4+CD25bright T regulatory (Treg) cells compared with their peripheral counterparts suggests that the CD4-CD25+ Treg cells may undergo maturation in the joint.
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Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays
TL;DR: parameters which are essential for measurement of cytokines in the context of clinical trials are shown, including blood collecting tubes, duration of storage, and number of freeze thawing cycles.