Author
Gerald B. Rich
Bio: Gerald B. Rich is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Obstructive sleep apnea & Sleep disorder. The author has an hindex of 3, co-authored 4 publications receiving 1478 citations.
Papers
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Shimane University1, University of Freiburg2, University of Manitoba3, University of Kentucky4, University of Marburg5, St. Michael's Hospital6, Baylor College of Medicine7, University of Illinois at Urbana–Champaign8, Scripps Health9, Oregon Health & Science University10, Tulane University11, Mayo Clinic12, Michigan State University13, Max Planck Society14, University of Göttingen15, University of California, Los Angeles16, Rutgers University17, Seton Hall University18
TL;DR: This scale meets performance criteria for a brief, patient completed instrument that can be used to assess RLS severity for purposes of clinical assessment, research, or therapeutic trials and supports a finding that RLS is a relatively uniform disorder in which the severity of the basic symptoms is strongly related to their impact on the patient's life.
1,439 citations
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TL;DR: Two nights of intermittent nocturnal hypoxemia during N CPAP treatment for OSAS did not diminish the objective improvement in daytime somnolence seen with NCPAP treatment in the absence ofNocturnal Hypoxemia, lending further support to the hypothesis relating excessive daytime sleepiness to sleep fragmentation.
174 citations
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3 citations
Cited by
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TL;DR: A systematic review of studies reporting LEDs yielded a standardized LED for each drug, providing a useful tool to express dose intensity of different antiparkinsonian drug regimens on a single scale.
Abstract: Interpretation of clinical trials comparing different drug regimens for Parkinson's disease (PD) is complicated by the different dose intensities used: higher doses of levodopa and, possibly, other drugs produce better symptomatic control but more late complications. To address this problem, conversion factors have been calculated for antiparkinsonian drugs that yield a total daily levodopa equivalent dose (LED). LED estimates vary, so we undertook a systematic review of studies reporting LEDs to provide standardized formulae. Electronic database and hand searching of references identified 56 primary reports of LED estimates. Data were extracted and the mean and modal LEDs calculated. This yielded a standardized LED for each drug, providing a useful tool to express dose intensity of different antiparkinsonian drug regimens on a single scale. Using these conversion formulae to report LEDs would improve the consistency of reporting and assist the interpretation of clinical trials comparing different PD medications.
3,379 citations
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TL;DR: Modification of the criteria for the diagnosis of restless legs syndrome is modified to better reflect that increased body of knowledge, as well as to clarify slight confusion with the wording of the original criteria.
2,834 citations
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TL;DR: These practice parameters are an update of the previously-published recommendations regarding the indications for polysomnography and related procedures in the diagnosis of sleep disorders.
Abstract: These practice parameters are an update of the previously-published recommendations regarding the indications for polysomnography and related procedures in the diagnosis of sleep disorders. Diagnostic categories include the following: sleep related breathing disorders, other respiratory disorders, narcolepsy, parasomnias, sleep related seizure disorders, restless legs syndrome, periodic limb movement sleep disorder, depression with insomnia, and circadian rhythm sleep disorders. Polysomnography is routinely indicated for the diagnosis of sleep related breathing disorders; for continuous positive airway pressure (CPAP) titration in patients with sleep related breathing disorders; for the assessment of treatment results in some cases; with a multiple sleep latency test in the evaluation of suspected narcolepsy; in evaluating sleep related behaviors that are violent or otherwise potentially injurious to the patient or others; and in certain atypical or unusual parasomnias. Polysomnography may be indicated in patients with neuromuscular disorders and sleep related symptoms; to assist in the diagnosis of paroxysmal arousals or other sleep disruptions thought to be seizure related; in a presumed parasomnia or sleep related seizure disorder that does not respond to conventional therapy; or when there is a strong clinical suspicion of periodic limb movement sleep disorder. Polysomnography is not routinely indicated to diagnose chronic lung disease; in cases of typical, uncomplicated, and noninjurious parasomnias when the diagnosis is clearly delineated; for patients with seizures who have no specific complaints consistent with a sleep disorder; to diagnose or treat restless legs syndrome; for the diagnosis of circadian rhythm sleep disorders; or to establish a diagnosis of depression.
1,883 citations
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TL;DR: The nature and consequences of upper-airway obstruction in adults during sleep has evolved considerably over the past two decades, and there is insufficient awareness of sleep apnea among physicians and the public at large.
Abstract: Our understanding of the nature and consequences of upper-airway obstruction in adults during sleep has evolved considerably over the past two decades. Sleep apnea — defined as repeated episodes of obstructive apnea and hypopnea during sleep, together with daytime sleepiness or altered cardiopulmonary function — is common.1 Epidemiologic studies estimate that the condition affects 2 to 4 percent of middle-aged adults.2 Only a small portion of the cases in this group of adults have been diagnosed; this is related to insufficient awareness of sleep apnea among physicians and the public at large.3 Definitions The manifestations of upper-airway closure during sleep . . .
1,314 citations
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TL;DR: No evidence is available on symptom prevalence in ESRD patients managed conservatively (without dialysis), but evidence in patients discontinuing dialysis suggests they too have significant symptom burden.
781 citations