Gerald C. Kolb

Bio: Gerald C. Kolb is an academic researcher from Dow Chemical Company. The author has contributed to research in topics: Monomer & Anhydrous. The author has an hindex of 3, co-authored 4 publications receiving 24 citations.

Polymer resulting from the cure of a preformed chromene-containing mixture

Abstract: This invention relates to a solvent process for the conversion of aromatic propargyl ethers into chromenes The process can be catalyzed with copper or zinc salts The preferred salt is cuprous chloride The most preferred solvent is a dichlorobenzene The invention also relates to chromene products formed using the process and to the polymerization of that chromene product and its polymerized product, the latter product having substantially improved flexural modulus and flexural strength properties The polymerized product is also moisture insensitive

Method for preparing 2-alkenyl-2-oxazolines

Abstract: The process comprises the steps of: (A) reacting by contacting an anhydrous or substantially anhydrous 2-alkyl-2-oxazoline with formaldehyde in a molar ratio of at least about 1.5 moles of 2-alkyl-2-oxazoline per mole of formaldehyde, thereby forming 2-(α-hydroxymethylalkyl)-2-oxazoline, (B) recovering the 2-(α-hydroxymethylalkyl)-2-oxazoline from the reaction product of step (A), and (C) reacting by contacting the 2-(α-hydroxymethylalkyl)-2-oxazoline and step B with an alkali or alkaline earth metal hydroxide, thereby forming 2-alkenyl-2-oxazoline. As an example, step A was conducted by reacting 2-ethyl-2-oxazoline (4 moles) having less than 1,000 ppm of water with paraformaldehyde (1 mole) at a reaction temperature of 100° C. for approximately 5.5 hours. The excess oxazoline reactant was removed along with water as "overheads" by fractional distillation of the reaction product, leaving the 2-(α-hydroxymethylethyl)-2-oxazoline in approximately 96 percent yield. Step C was then conducted by continuously adding the 2-(α-hydroxymethylethyl)-2-oxazoline to a stirred solution of sodium hydroxide in the mono-methyl ether of triethylene glycol at a temperature of from 100°-105° C. Under these conditions, the 2-isopropenyl-2-oxazoline and water were volatilized and recovered from the overheads. The product yield was approximately 98 percent of theory.

Process for the manufacture of oxazoline and/or oxazine-modified adsorbent polymer resins

Abstract: A novel process is disclosed for increasing the amount of grafted polymer formed during the production of polyamide-modified macroporous polystyrene/divinylbenzene cross-linked beads. Greater selectivity for oxazolination and/or oxazination (grafting) of the chloromethylated polystyrene (CMPS) beads over homopolymer formation is achieved by forming an iodized cross-linked vinyl-addition polymer which is then contacted with an excess of oxazoline or oxazine until up to about 50 percent of said oxazoline or oxazine monomer is reacted. Subsequent hydrolysis of these polyamide-modified resins produces polyamine anion-exchange resins which exhibit greater than 2 times the weak base capacities of conventional anion-exchange resins.

Azlactone graft copolymers

Abstract: Graft copolymers and processes for the preparation thereof are provided. The copolymers comprise a base polymer having grafted thereto a monomeric 2-alkenyl azlactone. The surface properties of the graft copolymers can be modified by binding thereto nucleophilic reagents comprising further functional groups with desired properties. Further, the amount of azlactone available at the surface of a graft copolymer for binding to such nucleophilic reagents can be controlled by selecting a surface against which the graft copolymer is formed. The graft copolymers exhibit desirable thermoplastic, melt flow, and adhesion properties and are particularly useful for immobilizing proteins. Methods of immunoassay based on the immobilization of proteins are also disclosed. Another utility of the graft copolymers involves the compatibilizing of immiscible polymer blends.

Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein

Abstract: The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an AβPP epitope spanning the β-secretase cleavage site of AβPP and a method for inducing an immune response against the β-secretase cleavage site of AβPP using this immunizing composition. The present invention is also directed to antibodies against the β-secretase cleavage site of AβPP and their use in a method for inhibiting the formation of amyloid β.

Bisphenol derivative therapeutics and methods for their use

Abstract: This invention provides compounds having a structure of Formula (I) Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided

Intermediate bulk container

Abstract: An intermediate bulk container (10) comprising a flexible storage container (12), a rigid rectangular base member including a plurality of pole engaging formations (30) on its upper surface which are arranged about its periphery, a plurality of poles (14), the lower end of each of which is releasably engageable with a pole engaging formation on the base so that the poles collectively provide a support cage for the storage container, a rigid pole location member (10) which includes a central opening through which the support container may be filled and a plurality of pole engaging formations with which the upper ends of the poles are releasably engageable, and bracing means connecting a pair of poles on at least two adjacent sides of the cage to each other for holding the poles, in the planes in which they are located in the assembled container, perpendicular to the base and pole locating member.

Humidity sensitive properties of quaternary ammonium salts containing polyelectrolytes crosslinked with 2-oxazoline crosslinker

Abstract: New 2-oxazoline group-containing copolymer crosslinkers for humidity-sensitive polyelectrolytes were prepared by copolymerization of [2-(methacryloyloxy)ethyl]trimethyl ammonium chloride (METAC), 2-isopropenyl-2-oxazoline (IPO) and n-butyl methacrylate (BMA). They were mutually crosslinkable with carboxylic acid-containing copolymers METAC/acrylic acid (AA)/BMA = 10/2/8. When the polyelectrolytes were applied to the humidity-sensitive membranes, the resistance varied from 107 to 103 Ω between 20% RH and 95% RH, which was required for a humidity sensor operating at ambient humidity. Temperature dependence, hysteresis, response time, water durability and long-term stability at high humidity were also measured and estimated.