Author
Gerald Klatskin
Other affiliations: Armed Forces Institute of Pathology, University of Florida
Bio: Gerald Klatskin is an academic researcher from Yale University. The author has contributed to research in topics: Cirrhosis & Liver disease. The author has an hindex of 42, co-authored 90 publications receiving 5901 citations. Previous affiliations of Gerald Klatskin include Armed Forces Institute of Pathology & University of Florida.
Papers published on a yearly basis
Papers
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TL;DR: The distinctive clinical and pathological features of adenocarcinomas of the hepatic duct at its bifurcation within the porta hepatis are described and palliative surgery aimed at relieving biliary obstruction may restore the patient to a good state of health for a remarkably long period of time.
742 citations
TL;DR: A multivariate analysis of clinical features revealed that at the onset of disease, age, hepatomegaly, and elevated levels of serum bilirubin were independent discriminators of a poor prognosis, and a histologic finding of fibrosis limited to portal areas improved this discrimination, correlating with prolonged survival.
Abstract: To determine the life expectancy of patients with primary biliary cirrhosis, we analyzed survival data from 280 patients with either symptomatic (243) or asymptomatic (37) disease. Patients were followed for up to 19 years (mean, 6.9 years). The average length of survival was 11.9 years--nearly twice that reported in other studies. In contrast, over a 12-year period the survival of the asymptomatic patients after diagnosis did not differ from that of a control population matched for age and sex. Jaundice, weight loss, hepatomegaly, splenomegaly, and ascites were each associated with a poor prognosis. Prognosis also correlated with the histologic stages of hepatic fibrosis, cholestasis, and periportal-cell necrosis. A multivariate analysis of clinical features revealed that at the onset of disease, age, hepatomegaly, and elevated levels of serum bilirubin were independent discriminators of a poor prognosis. A histologic finding of fibrosis limited to portal areas improved this discrimination, correlating with prolonged survival. No other factors enchanced the prediction of risk.
393 citations
TL;DR: It is demonstrated that patients who give up alcohol live significantly longer than those who continue to drink and that the life span in patients with Laennec's cirrhosis at the present time, whether or not they cease drinking, is significantly longer compared with that observed three decades ago.
305 citations
269 citations
TL;DR: The pattern of hepatic necrosis characterized by intralobular and interlobular bridging of portal triads or central veins, when found during the acute phase of viral hepatitis, indicates a severe form of the disease that may lead to fatal hepatic failure or the development of cirrhosis in a significant number of patients.
Abstract: Of 170 patients with biopsy-documented acute viral hepatitis, 52 exhibited zones of hepatic necrosis and collapse that bridged adjacent portal triads or central veins (or both), a lesion classified as subacute hepatic necrosis (SHN). Whereas the clinical course in the 118 patients with the classic type of spotty necrosis (CH) was relatively benign, 19 per cent of those with SHN lesions died, and cirrhosis developed in 37 per cent. Ascites, edema and hepatic coma, which occurred in approximately a quarter of the SHN patients, were the only clinical manifestations that clearly distinguished between the two groups. The pattern of hepatic necrosis characterized by intralobular and interlobular bridging of portal triads or central veins, when found during the acute phase of viral hepatitis, indicates a severe form of the disease that may lead to fatal hepatic failure or the development of cirrhosis in a significant number of patients.
217 citations
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TL;DR: Recombinant human alpha-interferon in patients with chronic nonA-nonB hepatitis and factors predictive of response to interferon alpha therapy in HCV infection are studied.
2,516 citations
TL;DR: Mise a jour: anatomopathologie, anomalies immunologiques et pathogenese, tests de laboratoire, manifestations cliniques et troubles associes, evolution, traitement.
Abstract: Mise a jour: anatomopathologie, anomalies immunologiques et pathogenese, tests de laboratoire, manifestations cliniques et troubles associes, evolution, traitement
1,939 citations
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05 Nov 2009
TL;DR: 结节病易误诊,据王洪武等~([1])收集国内18篇关于此第一印象中拟诊 结核5例,为此应引起临床对本 病诊
Abstract: 结节病易误诊,据王洪武等~([1])收集国内18篇关于此病误诊的文献,误诊率高达63.2%,当然有误诊就会有误治,如孙永昌等~([2])报道26例结节病在影像学检查诊断的第一印象中拟诊结核5例,其中就有2例完成规范的抗结核治疗,为此应引起临床对本病诊治的重视。
1,821 citations
TL;DR: The Type II hyperlipoproteinemia as mentioned in this paper is defined as an increase in the concentration of lipoproteins that have discrete β-mobility, and is defined by the Type II lipoprotein pattern.
Abstract: Type II Hyperlipoproteinemia159, 192 193 194 195 196 General Definitions By the Type II lipoprotein pattern we mean an increase in the concentration of lipoproteins that have discrete β mobility b
1,721 citations
TL;DR: The panel of experts, having emphasised the importance of initiating aetiologic treatment for any degree of hepatic disease at the earliest possible stage, extended its work to all the complications of cirrhosis which had not been covered by the European Association for the Study of the Liver guidelines.
1,534 citations