G
Gerald R. Cunha
Researcher at University of California, San Francisco
Publications - 373
Citations - 30733
Gerald R. Cunha is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Mesenchyme & Epithelium. The author has an hindex of 95, co-authored 365 publications receiving 29563 citations. Previous affiliations of Gerald R. Cunha include Monash University, Clayton campus & Baylor College of Medicine.
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Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
Journal ArticleDOI
Prostate cancer in a transgenic mouse.
Norman M. Greenberg,Francesco J. DeMayo,Milton J. Finegold,Daniel Medina,Wayne D. Tilley,J O Aspinall,Gerald R. Cunha,A A Donjacour,Robert J. Matusik,Jeffrey M. Rosen +9 more
TL;DR: The establishment of breeding lines of transgenic mice that reproducibly develop prostate cancer provides an animal model system to study the molecular basis of transformation of normal prostatic cells and the factors influencing the progression to metastatic prostate cancer.
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The Endocrinology and Developmental Biology of the Prostate
Gerald R. Cunha,Annemarie A. Donjacour,Paul S. Cooke,Paul S. Cooke,Sharron Mee,Robert M. Bigsby,Stephen J. Higgins,Yoshiki Sugimura +7 more
TL;DR: The most extensively studied gland of this group is the prostate, which is found exclusively in mammals and produces many components of semen such as fructose, zinc ions, and various proteins important for the formation of the copulatory plug in rodents.
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Roles for Nkx3.1 in prostate development and cancer
Rajula Bhatia-Gaur,Annemarie A. Donjacour,Peter J. Sciavolino,Peter J. Sciavolino,Minjung Kim,Minjung Kim,Nishita Desai,Nishita Desai,Peter Young,Christine R. Norton,Thomas Gridley,Robert D. Cardiff,Gerald R. Cunha,Cory Abate-Shen,Cory Abate-Shen,Michael M. Shen,Michael M. Shen +16 more
TL;DR: It is shown that the murine Nkx3.1 homeobox gene is the earliest known marker of prostate epithelium during embryogenesis and is subsequently expressed at all stages of prostate differentiation in vivo as well as in tissue recombinants.
Journal ArticleDOI
Estrogen Receptor β Inhibits Human Breast Cancer Cell Proliferation and Tumor Formation by Causing a G2 Cell Cycle Arrest
Sreenivasan Paruthiyil,Hema Parmar,Vaishali Kerekatte,Gerald R. Cunha,Gary L. Firestone,Dale C. Leitman +5 more
TL;DR: It is demonstrated that ERβ-selective estrogens may lack breast cancer promoting properties exhibited by estrogens in hormone replacement regimens and may be useful for chemoprevention of breast cancer.