G
Gerardo Gamba
Researcher at National Autonomous University of Mexico
Publications - 253
Citations - 15762
Gerardo Gamba is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Cotransporter & Distal convoluted tubule. The author has an hindex of 60, co-authored 236 publications receiving 14458 citations. Previous affiliations of Gerardo Gamba include Vanderbilt University Medical Center & National Institute of Nutrition, Hyderabad.
Papers
More filters
Journal ArticleDOI
Cloning and characterization of an extracellular Ca 2+ -sensing receptor from bovine parathyroid
Edward M. Brown,Gerardo Gamba,Daniela Riccardi,Michael Lombardi,Robert Butters,Olga Kifor,Adam Sun,Adam Sun,Matthias A. Hediger,Jonathan Lytton,Steven C. Hebert +10 more
TL;DR: The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor.
Journal ArticleDOI
Molecular Physiology and Pathophysiology of Electroneutral Cation-Chloride Cotransporters
TL;DR: This work is a comprehensive review of the knowledge that has evolved in this area and includes molecular biology of each gene, functional properties of identified cotransporters, structure-function relationships, and physiological and pathophysiological roles of each cotranporter.
Journal ArticleDOI
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.
Gerardo Gamba,Akihiko Miyanoshita,Michael Lombardi,Jonathan Lytton,Wen Sen Lee,Matthias A. Hediger,Steven C. Hebert +6 more
TL;DR: Northern blot analysis and in situ hybridization indicate that these transporters are expressed predominantly in kidney with an intrarenal distribution consistent with their recognized functional localization, establishing a new family of Na(+)-(K+)-Cl- cotransporters.
Journal ArticleDOI
Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor
TL;DR: In rat kidney, Northern analysis revealed RaKCaR transcripts of 4 and 7 kb, and in situ hybridization showed localization primarily in outer medulla and cortical medullary rays, which provide important insights into the molecular structure of an extracellular Ca2+/polyvalent cation-sensing receptor in rat kidney.
Journal ArticleDOI
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.
Frederick H. Wilson,Kristopher T. Kahle,Ernesto Sabath,Maria D. Lalioti,Alicia K. Rapson,Robert S. Hoover,Steven C. Hebert,Gerardo Gamba,Richard P. Lifton +8 more
TL;DR: It is demonstrated that WNK4 negatively regulates surface expression of NCCT and implicate loss of this regulation in the molecular pathogenesis of an inherited form of hypertension.