Gerhard Stöcklin

TL;DR: An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a maximum 50% in a synthesis time of approximately 50 min from EOB.

TL;DR: The high in vivo stability of L-FET, its fast brain and tumor uptake kinetics, its low accumulation in nontumor tissue and its ease of synthesis strongly support further evaluation of L-[18F]FET as an amino acid tracer for cerebral and peripheral tumors.

TL;DR: In vitro binding assays demonstrate that the introduction of tyrosine and subsequent iodination have no influence on the high affinity and selectivity for alpha(v)beta3, and the synthesis and biological evaluation of [125I]-3-iodo-D-Tyr4-cyclo(-Arg-Gly-Asp-D.Tyr-Val-) represents the first radiolabeled alpha( v) beta3 antagonist for the investigation of angiogenesis and metastasis

TL;DR: Owing to competing O-acylation of Tyr residues, [18F]fluoropropionylated HSA was partially unstable under slightly basic conditions, and 18F]SFB seems to be the most suitable 18F-labeling agent for proteins, particularly for the labeling of antibodies.

TL;DR: Kinetic analysis of 2-(18F)-fluoro-deoxy-glucose accumulation in patients with various brain tumors demonstrated that increased metabolic rates in tumors are mainly caused by altered phosphorylation rates while transport of glucose is less affected.