G
Gert Jan Fleuren
Researcher at Leiden University Medical Center
Publications - 285
Citations - 17885
Gert Jan Fleuren is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Antigen & Cancer. The author has an hindex of 68, co-authored 284 publications receiving 16982 citations. Previous affiliations of Gert Jan Fleuren include Leiden University & University of Groningen.
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Journal ArticleDOI
Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia
Gemma G. Kenter,Marij J. P. Welters,A. Rob P. M. Valentijn,Margriet J. G. Löwik,Dorien M A Berends-van der Meer,Annelies P G Vloon,Farah Essahsah,Lorraine M. Fathers,Rienk Offringa,Jan W. Drijfhout,Amon R. Wafelman,Jaap Oostendorp,Gert Jan Fleuren,Sjoerd H. van der Burg,Cornelis J. M. Melief +14 more
TL;DR: Clinical responses in women with HPV- 16-positive, grade 3 vulvar intraepithelial neoplasia can be achieved by vaccination with a synthetic long-peptide vaccine against the HPV-16 oncoproteins E6 and E7.
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KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas.
Vincent T.H.B.M. Smit,Angelina J.M. Boot,A M Smits,Gert Jan Fleuren,Cees J. Cornelisse,Johannes L. Bos +5 more
TL;DR: DNAs from human pancreatic adenocarcinomas were analyzed for the presence of mutations in codons 12, 13 and 61 of the NRAS, KRAS and HRAS gene and found a mutation in codon 12 of the KRAS gene, confirming the findings of Almoguera et al.
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Ep-CAM : a human epithelial antigen is a homophilic cell-cell adhesion molecule
TL;DR: It is demonstrated here that EGP40 is an epithelium-specific intercellular adhesion molecule that resembles to some extent the molecules of the immunoglobulin superfamily of cell adhesion molecules (CAMs), although no immunoglobeulin-like repeats are present in the EGP30 molecule.
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High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer
Sytse J. Piersma,Ekaterina S. Jordanova,Mariëtte I.E. van Poelgeest,Kitty M. C. Kwappenberg,Jeanette M. van der Hulst,Jan W. Drijfhout,Cornelis J. M. Melief,Gemma G. Kenter,Gert Jan Fleuren,Rienk Offringa,Sjoerd H. van der Burg +10 more
TL;DR: The data indicate that, especially in a sub group of LN- patients, a strong and effective interaction between immune system and tumor exists, and this subgroup of cervical cancer patients may have the best prognosis.
Journal ArticleDOI
Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine.
Marij J. P. Welters,Gemma G. Kenter,Sytse J. Piersma,Annelies P G Vloon,Margriet J. G. Löwik,Dorien M A Berends-van der Meer,Jan W. Drijfhout,A. Rob P. M. Valentijn,Amon R. Wafelman,Jaap Oostendorp,Gert Jan Fleuren,Rienk Offringa,Cornelis J. M. Melief,Sjoerd H. van der Burg +13 more
TL;DR: The HPV16 E6 and E7 synthetic long peptides vaccine is highly immunogenic, in that it increases the number and activity of HPV16-specific CD4+ and CD8+ T cells to a broad array of epitopes in all patients.