Gerth Stølting Brodal

Bio: Gerth Stølting Brodal is an academic researcher from Aarhus University. The author has contributed to research in topics: Data structure & Priority queue. The author has an hindex of 39, co-authored 166 publications receiving 4420 citations. Previous affiliations of Gerth Stølting Brodal include National Research Foundation of South Africa & Max Planck Society.

Computing the Quartet Distance between Evolutionary Trees in Time O(n log2 n)

Abstract: Evolutionary trees describing the relationship for a set of species are central in evolutionary biology, and quantifying differences between evolutionary trees is an important task. One previously proposed measure for this is the quartet distance. The quartet distance between two unrooted evolutionary trees is the number of quartet topology differences between the two trees, where a quartet topology is the topological subtree induced by four species. In this paper, we present an algorithm for computing the quartet distance between two unrooted evolutionary trees of n species in time O(n log2 n). The previous best algorithm runs in time O(n 2).

The Cost of Cache-Oblivious Searching

Abstract: This paper gives tight bounds on the cost of cache-oblivious searching. The paper shows that no cache-oblivious search structure can guarantee a search performance of fewer than lg elog B N memory transfers between any two levels of the memory hierarchy. This lower bound holds even if all of the block sizes are limited to be powers of 2. The paper gives modified versions of the van Emde Boas layout, where the expected number of memory transfers between any two levels of the memory hierarchy is arbitrarily close to [lg e+O(lg lg B/lg B)]log B N+O(1). This factor approaches lg e≈1.443 as B increases. The expectation is taken over the random placement in memory of the first element of the structure. Because searching in the disk-access machine (DAM) model can be performed in log B N+O(1) block transfers, this result establishes a separation between the (2-level) DAM model and cache-oblivious model. The DAM model naturally extends to k levels. The paper also shows that as k grows, the search costs of the optimal k-level DAM search structure and the optimal cache-oblivious search structure rapidly converge. This result demonstrates that for a multilevel memory hierarchy, a simple cache-oblivious structure almost replicates the performance of an optimal parameterized k-level DAM structure.

Dynamic matchings in convex bipartite graphs

Abstract: We consider the problem of maintaining a maximum matching in a convex bipartite graph G = (V,E) under a set of update operations which includes insertions and deletions of vertices and edges. It is not hard to show that it is impossible to maintain an explicit representation of a maximum matching in sub-linear time per operation, even in the amortized sense. Despite this difficulty, we develop a data structure which maintains the set of vertices that participate in a maximum matching in O(log2 |V|) amortized time per update and reports the status of a vertex (matched or unmatched) in constant worst-case time. Our structure can report the mate of a matched vertex in the maximum matching in worst-case O(min{k log2 |V |+log |V|, |V| log |V|}) time, where k is the number of update operations since the last query for the same pair of vertices was made. In addition, we give an O(√|V| log2 |V|)-time amortized bound for this pair query.

Fast Meldable Priority Queues

Abstract: We present priority queues that support the operations MakeQueue, FindMin, Insert and Meld in worst case time O(1) and Delete and DeleteMin in worst case time O(log n). They can be implemented on the pointer machine and require linear space. The time bounds are optimal for all implementations where Meld takes worst case time o(n). To our knowledge this is the first priority queue implementation that supports Meld in worst case constant time and DeleteMin in logarithmic time.

Application of Phylogenetic Networks in Evolutionary Studies

Abstract: The evolutionary history of a set of taxa is usually represented by a phylogenetic tree, and this model has greatly facilitated the discussion and testing of hypotheses. However, it is well known that more complex evolutionary scenarios are poorly described by such models. Further, even when evolution proceeds in a tree-like manner, analysis of the data may not be best served by using methods that enforce a tree structure but rather by a richer visualization of the data to evaluate its properties, at least as an essential first step. Thus, phylogenetic networks should be employed when reticulate events such as hybridization, horizontal gene transfer, recombination, or gene duplication and loss are believed to be involved, and, even in the absence of such events, phylogenetic networks have a useful role to play. This article reviews the terminology used for phylogenetic networks and covers both split networks and reticulate networks, how they are defined, and how they can be interpreted. Additionally, the article outlines the beginnings of a comprehensive statistical framework for applying split network methods. We show how split networks can represent confidence sets of trees and introduce a conservative statistical test for whether the conflicting signal in a network is treelike. Finally, this article describes a new program, SplitsTree4, an interactive and comprehensive tool for inferring different types of phylogenetic networks from sequences, distances, and trees.

FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix

Abstract: Gene families are growing rapidly, but standard methods for inferring phylogenies do not scale to alignments with over 10,000 sequences. We present FastTree, a method for constructing large phylogenies and for estimating their reliability. Instead of storing a distance matrix, FastTree stores sequence profiles of internal nodes in the tree. FastTree uses these profiles to implement Neighbor-Joining and uses heuristics to quickly identify candidate joins. FastTree then uses nearest neighbor interchanges to reduce the length of the tree. For an alignment with N sequences, L sites, and a different characters, a distance matrix requires O(N2) space and O(N2L) time, but FastTree requires just O(NLa + N) memory and O(Nlog (N)La) time. To estimate the tree's reliability, FastTree uses local bootstrapping, which gives another 100-fold speedup over a distance matrix. For example, FastTree computed a tree and support values for 158,022 distinct 16S ribosomal RNAs in 17 h and 2.4 GB of memory. Just computing pairwise Jukes–Cantor distances and storing them, without inferring a tree or bootstrapping, would require 17 h and 50 GB of memory. In simulations, FastTree was slightly more accurate than Neighbor-Joining, BIONJ, or FastME; on genuine alignments, FastTree's topologies had higher likelihoods. FastTree is available at http://microbesonline.org/fasttree.

Fast Tree: Computing Large Minimum-Evolution Trees with Profiles instead of a Distance Matrix

Abstract: Gene families are growing rapidly, but standard methods for inferring phylogenies do not scale to alignments with over 10,000 sequences. We present FastTree, a method for constructing large phylogenies and for estimating their reliability. Instead of storing a distance matrix, FastTree stores sequence profiles of internal nodes in the tree. FastTree uses these profiles to implement neighbor-joining and uses heuristics to quickly identify candidate joins. FastTree then uses nearest-neighbor interchanges to reduce the length of the tree. For an alignment with N sequences, L sites, and a different characters, a distance matrix requires O(N^2) space and O(N^2 L) time, but FastTree requires just O( NLa + N sqrt(N) ) memory and O( N sqrt(N) log(N) L a ) time. To estimate the tree's reliability, FastTree uses local bootstrapping, which gives another 100-fold speedup over a distance matrix. For example, FastTree computed a tree and support values for 158,022 distinct 16S ribosomal RNAs in 17 hours and 2.4 gigabytes of memory. Just computing pairwise Jukes-Cantor distances and storing them, without inferring a tree or bootstrapping, would require 17 hours and 50 gigabytes of memory. In simulations, FastTree was slightly more accurate than neighbor joining, BIONJ, or FastME; on genuine alignments, FastTree's topologies had higher likelihoods. FastTree is available at http://microbesonline.org/fasttree.

BOLD : The Barcode of Life Data System (www.barcodinglife.org)

Abstract: The Barcode of Life Data System ( BOLD ) is an informatics workbench aiding the acquisition, storage, analysis and publication of DNA barcode records. By assembling molecular, morphological and distributional data, it bridges a traditional bioinformatics chasm. BOLD is freely available to any researcher with interests in DNA barcoding. By providing specialized services, it aids the assembly of records that meet the standards needed to gain BARCODE designation in the global sequence databases. Because of its web-based delivery and flexible data security model, it is also well positioned to support projects that involve broad research alliances. This paper provides a brief introduction to the key elements of BOLD , discusses their functional capabilities, and concludes by examining computational resources and future prospects.