Gerth Stølting Brodal

Bio: Gerth Stølting Brodal is an academic researcher from Aarhus University. The author has contributed to research in topics: Data structure & Priority queue. The author has an hindex of 39, co-authored 166 publications receiving 4420 citations. Previous affiliations of Gerth Stølting Brodal include National Research Foundation of South Africa & Max Planck Society.

Cache Oblivious Distribution Sweeping

Abstract: We adapt the distribution sweepingmetho d to the cache oblivious model. Distribution sweepingis the name used for a general approach for divide-and-conquer algorithms where the combination of solved subproblems can be viewed as a merging process of streams. We demonstrate by a series of algorithms for specific problems the feasibility of the method in a cache oblivious setting. The problems all come from computational geometry, and are: orthogonal line segment intersection reporting, the all nearest neighbors problem, the 3D maxima problem, computingthe measure of a set of axis-parallel rectangles, computingthe visibility of a set of line segments from a point, batched orthogonal range queries, and reportingpairwise intersections of axis-parallel rectangles. Our basic buildingblo ck is a simplified version of the cache oblivious sorting algorithm Funnelsort of Frigo et al., which is of independent interest.

On External-Memory MST, SSSP, and Multi-way Planar Graph Separation

Abstract: Recently external memory graph algorithms have received considerable attention because massive graphs arise naturally in many applications involving massive data sets. Even though a large number of I/O-efficient graph algorithms have been developed, a number of fundamental problems still remain open. In this paper we develop an improved algorithm for the problem of computing a minimum spanning tree of a general graph, as well as new algorithms for the single source shortest paths and the multi-way graph separation problems on planar graphs.

Optimal static range reporting in one dimension

Abstract: We consider static one dimensional range searching problems. These problems are to build static data structures for an integer set S \subseteq U, where U = \{0,1,\dots,2^w-1\}, which support various queries for integer intervals of U. For the query of reporting all integers in S contained within a query interval, we present an optimal data structure with linear space cost and with query time linear in the number of integers reported. This result holds in the unit cost RAM model with word size w and a standard instruction set. We also present a linear space data structure for approximate range counting. A range counting query for an interval returns the number of integers in S contained within the interval. For any constant e>0, our range counting data structure returns in constant time an approximate answer which is within a factor of at most 1+e of the correct answer.

On the limits of cache-obliviousness

Abstract: In this paper, we present lower bounds for permuting and sorting in the cache-oblivious model. We prove that (1) I/O optimal cache-oblivious comparison based sorting is not possible without a tall cache assumption, and (2) there does not exist an I/O optimal cache-oblivious algorithm for permuting, not even in the presence of a tall cache assumption.Our results for sorting show the existence of an inherent trade-off in the cache-oblivious model between the strength of the tall cache assumption and the overhead for the case M » B, and show that Funnelsort and recursive binary mergesort are optimal algorithms in the sense that they attain this trade-off.

Dynamic Representation of Sparse Graphs

Abstract: We present a linear space data structure for maintaining graphs with bounded arboricity--a large class of sparse graphs containing e.g. planar graphs and graphs of bounded treewidth--under edge insertions, edge deletions, and adjacency queries. The data structure supports adjacency queries in worst case O(c) time, and edge insertions and edge deletions in amortized O(1) and O(c+log n) time, respectively, where n is the number of nodes in the graph, and c is the bound on the arboricity.

Application of Phylogenetic Networks in Evolutionary Studies

Abstract: The evolutionary history of a set of taxa is usually represented by a phylogenetic tree, and this model has greatly facilitated the discussion and testing of hypotheses. However, it is well known that more complex evolutionary scenarios are poorly described by such models. Further, even when evolution proceeds in a tree-like manner, analysis of the data may not be best served by using methods that enforce a tree structure but rather by a richer visualization of the data to evaluate its properties, at least as an essential first step. Thus, phylogenetic networks should be employed when reticulate events such as hybridization, horizontal gene transfer, recombination, or gene duplication and loss are believed to be involved, and, even in the absence of such events, phylogenetic networks have a useful role to play. This article reviews the terminology used for phylogenetic networks and covers both split networks and reticulate networks, how they are defined, and how they can be interpreted. Additionally, the article outlines the beginnings of a comprehensive statistical framework for applying split network methods. We show how split networks can represent confidence sets of trees and introduce a conservative statistical test for whether the conflicting signal in a network is treelike. Finally, this article describes a new program, SplitsTree4, an interactive and comprehensive tool for inferring different types of phylogenetic networks from sequences, distances, and trees.

FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix

Abstract: Gene families are growing rapidly, but standard methods for inferring phylogenies do not scale to alignments with over 10,000 sequences. We present FastTree, a method for constructing large phylogenies and for estimating their reliability. Instead of storing a distance matrix, FastTree stores sequence profiles of internal nodes in the tree. FastTree uses these profiles to implement Neighbor-Joining and uses heuristics to quickly identify candidate joins. FastTree then uses nearest neighbor interchanges to reduce the length of the tree. For an alignment with N sequences, L sites, and a different characters, a distance matrix requires O(N2) space and O(N2L) time, but FastTree requires just O(NLa + N) memory and O(Nlog (N)La) time. To estimate the tree's reliability, FastTree uses local bootstrapping, which gives another 100-fold speedup over a distance matrix. For example, FastTree computed a tree and support values for 158,022 distinct 16S ribosomal RNAs in 17 h and 2.4 GB of memory. Just computing pairwise Jukes–Cantor distances and storing them, without inferring a tree or bootstrapping, would require 17 h and 50 GB of memory. In simulations, FastTree was slightly more accurate than Neighbor-Joining, BIONJ, or FastME; on genuine alignments, FastTree's topologies had higher likelihoods. FastTree is available at http://microbesonline.org/fasttree.

Fast Tree: Computing Large Minimum-Evolution Trees with Profiles instead of a Distance Matrix

Abstract: Gene families are growing rapidly, but standard methods for inferring phylogenies do not scale to alignments with over 10,000 sequences. We present FastTree, a method for constructing large phylogenies and for estimating their reliability. Instead of storing a distance matrix, FastTree stores sequence profiles of internal nodes in the tree. FastTree uses these profiles to implement neighbor-joining and uses heuristics to quickly identify candidate joins. FastTree then uses nearest-neighbor interchanges to reduce the length of the tree. For an alignment with N sequences, L sites, and a different characters, a distance matrix requires O(N^2) space and O(N^2 L) time, but FastTree requires just O( NLa + N sqrt(N) ) memory and O( N sqrt(N) log(N) L a ) time. To estimate the tree's reliability, FastTree uses local bootstrapping, which gives another 100-fold speedup over a distance matrix. For example, FastTree computed a tree and support values for 158,022 distinct 16S ribosomal RNAs in 17 hours and 2.4 gigabytes of memory. Just computing pairwise Jukes-Cantor distances and storing them, without inferring a tree or bootstrapping, would require 17 hours and 50 gigabytes of memory. In simulations, FastTree was slightly more accurate than neighbor joining, BIONJ, or FastME; on genuine alignments, FastTree's topologies had higher likelihoods. FastTree is available at http://microbesonline.org/fasttree.

BOLD : The Barcode of Life Data System (www.barcodinglife.org)

Abstract: The Barcode of Life Data System ( BOLD ) is an informatics workbench aiding the acquisition, storage, analysis and publication of DNA barcode records. By assembling molecular, morphological and distributional data, it bridges a traditional bioinformatics chasm. BOLD is freely available to any researcher with interests in DNA barcoding. By providing specialized services, it aids the assembly of records that meet the standards needed to gain BARCODE designation in the global sequence databases. Because of its web-based delivery and flexible data security model, it is also well positioned to support projects that involve broad research alliances. This paper provides a brief introduction to the key elements of BOLD , discusses their functional capabilities, and concludes by examining computational resources and future prospects.