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Getachew Redae Taffere

Bio: Getachew Redae Taffere is an academic researcher from University of Washington. The author has contributed to research in topics: Global health & Life expectancy. The author has an hindex of 6, co-authored 6 publications receiving 12610 citations.

Papers
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Journal ArticleDOI
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016.

10,401 citations

Journal ArticleDOI
TL;DR: At a global level, DALYs and HALE continue to show improvements and the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning.

3,029 citations

Journal ArticleDOI
TL;DR: The findings show substantial progress in the reduction of lower respiratory infection burden, but this progress has not been equal across locations, has been driven by decreases in several primary risk factors, and might require more effort among elderly adults.
Abstract: Summary Background Lower respiratory infections are a leading cause of morbidity and mortality around the world The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016, provides an up-to-date analysis of the burden of lower respiratory infections in 195 countries This study assesses cases, deaths, and aetiologies spanning the past 26 years and shows how the burden of lower respiratory infection has changed in people of all ages Methods We used three separate modelling strategies for lower respiratory infections in GBD 2016: a Bayesian hierarchical ensemble modelling platform (Cause of Death Ensemble model), which uses vital registration, verbal autopsy data, and surveillance system data to predict mortality due to lower respiratory infections; a compartmental meta-regression tool (DisMod-MR), which uses scientific literature, population representative surveys, and health-care data to predict incidence, prevalence, and mortality; and modelling of counterfactual estimates of the population attributable fraction of lower respiratory infection episodes due to Streptococcus pneumoniae, Haemophilus influenzae type b, influenza, and respiratory syncytial virus We calculated each modelled estimate for each age, sex, year, and location We modelled the exposure level in a population for a given risk factor using DisMod-MR and a spatio-temporal Gaussian process regression, and assessed the effectiveness of targeted interventions for each risk factor in children younger than 5 years We also did a decomposition analysis of the change in LRI deaths from 2000–16 using the risk factors associated with LRI in GBD 2016 Findings In 2016, lower respiratory infections caused 652 572 deaths (95% uncertainty interval [UI] 586 475–720 612) in children younger than 5 years (under-5s), 1 080 958 deaths (943 749–1 170 638) in adults older than 70 years, and 2 377 697 deaths (2 145 584–2 512 809) in people of all ages, worldwide Streptococcus pneumoniae was the leading cause of lower respiratory infection morbidity and mortality globally, contributing to more deaths than all other aetiologies combined in 2016 (1 189 937 deaths, 95% UI 690 445–1 770 660) Childhood wasting remains the leading risk factor for lower respiratory infection mortality among children younger than 5 years, responsible for 61·4% of lower respiratory infection deaths in 2016 (95% UI 45·7–69·6) Interventions to improve wasting, household air pollution, ambient particulate matter pollution, and expanded antibiotic use could avert one under-5 death due to lower respiratory infection for every 4000 children treated in the countries with the highest lower respiratory infection burden Interpretation Our findings show substantial progress in the reduction of lower respiratory infection burden, but this progress has not been equal across locations, has been driven by decreases in several primary risk factors, and might require more effort among elderly adults By highlighting regions and populations with the highest burden, and the risk factors that could have the greatest effect, funders, policy makers, and programme implementers can more effectively reduce lower respiratory infections among the world's most susceptible populations Funding Bill & Melinda Gates Foundation

1,147 citations

Journal ArticleDOI
Christopher Troeger, Brigette F. Blacker, Ibrahim A Khalil, Puja C Rao, Shujin Cao, Stephanie R. M. Zimsen, Samuel B. Albertson, Jeffery D Stanaway, Aniruddha Deshpande, Zegeye Abebe, Nelson Alvis-Guzman, Azmeraw T. Amare, Solomon Weldegebreal Asgedom, Zelalem Alamrew Anteneh, Carl Abelardo T. Antonio, Olatunde Aremu, Ephrem Tsegay Asfaw, Tesfay Mehari Atey, Suleman Atique, Euripide Frinel G Arthur Avokpaho, Ashish Awasthi, Henok Tadesse Ayele, Aleksandra Barac, Mauricio Lima Barreto, Quique Bassat, Saba Abraham Belay, Isabela M. Benseñor, Zulfiqar A Bhutta, Ali Bijani, Hailemichael Bizuneh, Carlos A Castañeda-Orjuela, Abel Fekadu Dadi, Lalit Dandona, Rakhi Dandona, Huyen Phuc Do, Manisha Dubey, Eleonora Dubljanin, Dumessa Edessa, Aman Yesuf Endries, Babak Eshrati, Tamer H. Farag, Garumma Tolu Feyissa, Kyle J Foreman, Mohammad H. Forouzanfar, Nancy Fullman, Peter W. Gething, Melkamu Dedefo Gishu, William W Godwin, Harish Chander Gugnani, Rashmi Gupta, Gessessew Bugssa Hailu, Hamid Yimam Hassen, Desalegn Tsegaw Hibstu, Olayinka Stephen Ilesanmi, Jost B. Jonas, Amaha Kahsay, Gagandeep Kang, Amir Kasaeian, Yousef Khader, Ejaz Ahmad Khan, Muhammad Ali Khan, Young-Ho Khang, Niranjan Kissoon, Sonali Kochhar, Karen L. Kotloff, Ai Koyanagi, G Anil Kumar, Hassan Magdy Abd El Razek, Reza Malekzadeh, Deborah Carvalho Malta, Suresh Mehata, Walter Mendoza, Desalegn Tadese Mengistu, Bereket Gebremichael Menota, Haftay Berhane Mezgebe, Fitsum Weldegebreal Mlashu, Srinivas Murthy, Gurudatta Naik, Cuong Tat Nguyen, Trang Huyen Nguyen, Dina Nur Anggraini Ningrum, Felix Akpojene Ogbo, Andrew T Olagunju, Deepak Paudel, James A Platts-Mills, Mostafa Qorbani, Anwar Rafay, Rajesh Kumar Rai, Saleem M Rana, Chhabi Lal Ranabhat, Davide Rasella, Sarah E Ray, Cesar Reis, Andre M. N. Renzaho, Mohammad Sadegh Rezai, George Mugambage Ruhago, Saeid Safiri, Joshua A. Salomon, Juan Sanabria, Benn Sartorius, Monika Sawhney, Sadaf G. Sepanlou, Mika Shigematsu, Mekonnen Sisay, Ranjani Somayaji, Chandrashekhar T Sreeramareddy, Bryan L. Sykes, Getachew Redae Taffere, Roman Topor-Madry, Bach Xuan Tran, Kald Beshir Tuem, Kingsley N. Ukwaja, Stein Emil Vollset, Judd L. Walson, Marcia R. Weaver, Kidu Gidey Weldegwergs, Andrea Werdecker, Abdulhalik Workicho, Muluken Azage Yenesew, Biruck Desalegn Yirsaw, Naohiro Yonemoto, Maysaa El Sayed Zaki, Theo Vos, Stephen S Lim, Mohsen Naghavi, Christopher J L Murray, Ali H. Mokdad, Simon I. Hay, Robert Reiner 
TL;DR: Substantial progress has been made globally in reducing the burden of diarrhoeal diseases, driven by decreases in several primary risk factors, however, this reduction has not been equal across locations, and burden among adults older than 70 years requires attention.
Abstract: Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 provides an up-to-date analysis of the burden of diarrhoea in 195 countries. This study assesses cases, deaths, and aetiologies in 1990–2016 and assesses how the burden of diarrhoea has changed in people of all ages. Methods We modelled diarrhoea mortality with a Bayesian hierarchical modelling platform that evaluates a wide range of covariates and model types on the basis of vital registration and verbal autopsy data. We modelled diarrhoea incidence with a compartmental meta-regression tool that enforces an association between incidence and prevalence, and relies on scientific literature, population representative surveys, and health-care data. Diarrhoea deaths and episodes were attributed to 13 pathogens by use of a counterfactual population attributable fraction approach. Diarrhoea risk factors are also based on counterfactual estimates of risk exposure and the association between the risk and diarrhoea. Each modelled estimate accounted for uncertainty. Findings In 2016, diarrhoea was the eighth leading cause of death among all ages (1 655 944 deaths, 95% uncertainty interval [UI] 1 244 073–2 366 552) and the fifth leading cause of death among children younger than 5 years (446 000 deaths, 390 894–504 613). Rotavirus was the leading aetiology for diarrhoea mortality among children younger than 5 years (128 515 deaths, 105 138–155 133) and among all ages (228 047 deaths, 183 526–292 737). Childhood wasting (low weight-for-height score), unsafe water, and unsafe sanitation were the leading risk factors for diarrhoea, responsible for 80·4% (95% UI 68·2–85·0), 72·1% (34·0–91·4), and 56·4% (49·3–62·7) of diarrhoea deaths in children younger than 5 years, respectively. Prevention of wasting in 1762 children (95% UI 1521–2170) could avert one death from diarrhoea. Interpretation Substantial progress has been made globally in reducing the burden of diarrhoeal diseases, driven by decreases in several primary risk factors. However, this reduction has not been equal across locations, and burden among adults older than 70 years requires attention. Funding Bill & Melinda Gates Foundation.

787 citations

Journal ArticleDOI
TL;DR: The pace of progress achieved between 1990 and 2016 varied, with markedly faster improvements occurring between 2000 and 2016 for many countries in sub-Saharan Africa and southeast Asia, whereas several countries in Latin America and elsewhere saw progress stagnate after experiencing considerable advances in the HAQ Index between1990 and 2000.

623 citations


Cited by
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Journal ArticleDOI
TL;DR: Authors/Task Force Members: Piotr Ponikowski* (Chairperson) (Poland), Adriaan A. Voors* (Co-Chair person) (The Netherlands), Stefan D. Anker (Germany), Héctor Bueno (Spain), John G. F. Cleland (UK), Andrew J. S. Coats (UK)

13,400 citations

Journal ArticleDOI
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016.

10,401 citations

Journal ArticleDOI
Theo Vos1, Theo Vos2, Theo Vos3, Stephen S Lim  +2416 moreInstitutions (246)
TL;DR: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates, and there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries.

5,802 citations

Journal ArticleDOI
TL;DR: The sources and methods used in compiling the cancer statistics in 185 countries are reviewed, and uncertainty intervals are now provided for the estimated sex‐ and site‐specific all‐ages number of new cancer cases and cancer deaths.
Abstract: Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer statistics in 185 countries. The validity of the national estimates depends upon the representativeness of the source information, and to take into account possible sources of bias, uncertainty intervals are now provided for the estimated sex- and site-specific all-ages number of new cancer cases and cancer deaths. We briefly describe the key results globally and by world region. There were an estimated 18.1 million (95% UI: 17.5-18.7 million) new cases of cancer (17 million excluding non-melanoma skin cancer) and 9.6 million (95% UI: 9.3-9.8 million) deaths from cancer (9.5 million excluding non-melanoma skin cancer) worldwide in 2018.

4,924 citations

Journal ArticleDOI
TL;DR: Just under half a billion people are living with diabetes worldwide and the number is projected to increase by 25% in 2030 and 51% in 2045, with the prevalence higher in urban than rural areas, and in high-income than low-income countries.

4,865 citations