G
Geum-Hwa Lee
Researcher at Chonbuk National University
Publications - 51
Citations - 1418
Geum-Hwa Lee is an academic researcher from Chonbuk National University. The author has contributed to research in topics: Endoplasmic reticulum & Unfolded protein response. The author has an hindex of 19, co-authored 43 publications receiving 1129 citations.
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Journal ArticleDOI
Bax Inhibitor-1 Regulates Endoplasmic Reticulum Stress-associated Reactive Oxygen Species and Heme Oxygenase-1 Expression
Geum-Hwa Lee,Hyun-Kyung Kim,Soo-Wan Chae,Do-Sung Kim,Ki-Chan Ha,Mike Cuddy,Christina L. Kress,John C. Reed,Hyung-Ryong Kim,Han-Jung Chae +9 more
TL;DR: It is shown that the response of unfolded proteins is followed by ROS accumulation under ER stress, which is regulated in BI-1 cells, and HO-1 plays an important role in the BI- 1-associated protection against ER stress.
Journal ArticleDOI
Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1.
TL;DR: Investigation of the molecular mechanism by which Bax inhibitor 1 abrogates the accumulation of reactive oxygen species (ROS) in the endoplasmic reticulum suggests that the flow of electrons from NPR to P450 2E1 can be modulated by BI1.
Journal ArticleDOI
Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial KATP channels
Cheng Shi Piao,Shan Gao,Geum-Hwa Lee,Do-Sung Kim,Byung-Hyun Park,Soo Wan Chae,Han-Jung Chae,Suhn Hee Kim +7 more
TL;DR: The results suggest that the protective effects of sulforaphane against I/R injury may be partly mediated through mitochondrial K(ATP) channels and antioxidant pathway.
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Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress
Yong-Joo Shin,Song-Hee Han,Do-Sung Kim,Geum-Hwa Lee,Wan-Hee Yoo,Yong-Mo Kang,Je-Yong Choi,Yong Chul Lee,Seoung Ju Park,Seul-Ki Jeong,Hyung-Tae Kim,Soo-Wan Chae,Hyun-Ja Jeong,Hyung-Ryong Kim,Han-Jung Chae +14 more
TL;DR: Autophagy induction and CHOP under-expression increases cell resistance against ER stress-induced cell death in fibroblasts from rheumatoid arthritis patients.
Journal ArticleDOI
Effects of Ficus carica paste on loperamide-induced constipation in rats.
Hak-Yong Lee,Jung-Hoon Kim,Han-Wool Jeung,Cha-Uk Lee,Do-Sung Kim,Bo Li,Geum-Hwa Lee,Myung-Soon Sung,Ki-Chan Ha,Hyang-Im Back,Sun-Young Kim,Soo Hyun Park,Mi-Ra Oh,Min-Gul Kim,Ji-Young Jeon,Yong-Jin Im,Min-Ho Hwang,Byung-Ok So,Sook-Jeong Shin,Wan-Hee Yoo,Hyung-Ryong Kim,Han-Jung Chae,Soo-Wan Chae +22 more
TL;DR: Constipation was decreased when fig fruit was fed to rats and fecal number, weight, and water content, as well as histological parameters such as thickness and mucin areas in the distal colon were improved.