Author
Ghanshyam Pandey
Bio: Ghanshyam Pandey is an academic researcher from Indian Institute of Technology Kanpur. The author has contributed to research in topics: Lewis acids and bases & Cleavage (embryo). The author has an hindex of 4, co-authored 8 publications receiving 228 citations.
Papers
More filters
TL;DR: In this paper, the reactions of alkyl nitriles, acetyl chloride, aldehydes and simple ketones were studied for the one-pot synthesis of β-acetamido carbonyl compounds.
131 citations
TL;DR: In this paper, an efficient synthesis of 2,4-disubstituted 1H-imidazolines from aziridines and nitriles in the presence of BF3-Et2O or triethyloxonium tetrafluoroborate has been described.
48 citations
TL;DR: A variety of aziridines were opened in an efficient manner with aromatic amines using silica gel under solvent free conditions as mentioned in this paper, where the amine amines were formed by a mixture of amine derivatives.
34 citations
TL;DR: In this article, a variety of activated aziridines were cleaved by sodium azide and sodium cyanide in aqueous acetonitrile at reflux, in the absence of any Lewis acid, to provide ring-opened products in quantitative yields.
17 citations
TL;DR: A variety of aziridines were opened in an efficient manner with aromatic amines using silica gel under solvent free conditions as discussed by the authors, where the amine amines were formed by a mixture of amine derivatives.
Abstract: A variety of aziridines were opened in an efficient manner with aromatic amines using silica gel under solvent free conditions.
3 citations
Cited by
More filters
TL;DR: In this Review, the fundamental characteristics of azide chemistry and current developments are presented and the focus will be placed on cycloadditions (Huisgen reaction), aza ylide chemistry, and the synthesis of heterocycles.
Abstract: Since the discovery of organic azides by Peter Griess more than 140 years ago, numerous syntheses of these energy-rich molecules have been developed. In more recent times in particular, completely new perspectives have been developed for their use in peptide chemistry, combinatorial chemistry, and heterocyclic synthesis. Organic azides have assumed an important position at the interface between chemistry, biology, medicine, and materials science. In this Review, the fundamental characteristics of azide chemistry and current developments are presented. The focus will be placed on cycloadditions (Huisgen reaction), aza ylide chemistry, and the synthesis of heterocycles. Further reactions such as the aza-Wittig reaction, the Sundberg rearrangement, the Staudinger ligation, the Boyer and Boyer-Aube rearrangements, the Curtius rearrangement, the Schmidt rearrangement, and the Hemetsberger rearrangement bear witness to the versatility of modern azide chemistry.
1,766 citations
741 citations
TL;DR: In this paper, the authors summarized the results reported mainly within the last 10 years, and it is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis.
Abstract: Multicomponent reactions have gained significant importance as a tool for the synthesis of a wide variety of useful compounds, including pharmaceuticals. In this context, the multiple component approach is especially appealing in view of the fact that products are formed in a single step, and the diversity can be readily achieved simply by varying the reacting components. The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for conducting rapid organic synthesis and functional group transformations more efficiently. Additionally, there are distinct advantages of these solvent-free protocols since they provide reduction or elimination of solvents thereby preventing pollution in organic synthesis “at source”. The chemo-, regio- or stereoselective synthesis of high-value chemical entities and parallel synthesis to generate a library of small molecules will add to the growth of multicomponent solvent-free reactions in the near future. In this review we summarized the results reported mainly within the last 10 years. It is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis. Therefore, diversity oriented synthesis (DOS) is rapidly becoming one of the paradigms in the process of modern drug discovery. This has spurred research in those fields of chemical investigation that lead to the rapid assembly of not only molecular diversity, but also molecular complexity. As a consequence multi-component as well as domino or related reactions are witnessing a new spring.
420 citations
TL;DR: This overview should allow chemists to gain insight into the factors governing the regioselectivity in aziridinium ring openings and inherent structural features such as the nature of the C2 aziridine substituent and the natureof the electrophile and the nucleophile.
Abstract: In this critical review, the ring opening of non-activated 2-substituted aziridinesvia intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship between the observed regioselectivity and inherent structural features such as the nature of the C2 aziridine substituent and the nature of the electrophile and the nucleophile. This overview should allow chemists to gain insight into the factors governing the regioselectivity in aziridinium ring openings (81 references).
360 citations
TL;DR: Aza-Ylidchemie, Aza-wittig-Reaktion, Sundberg-Umlagerung, Staudinger-Ligation, Boyer-Boyer and Boyer Aube-Aube-UMLagerung as discussed by the authors, Curtius-Universität, Schmidt-Ummagerung sowie die Hemetsberger-Umbagerung zeugen von der Vielfaltigkeit moderner Azid-Chemie, and aktuelle Entwicklungen auf dem interdis
Abstract: Seit der Entdeckung der organischen Azide vor uber einhundertvierzig Jahren durch Peter Gries wurde eine Reihe von Synthesen fur diese energiereichen Molekule entwickelt. In letzter Zeit haben sich vollig neue Perspektiven durch Anwendungen in der Peptidchemie, der kombinatorischen Chemie und der Heterocyclensynthese ergeben. Auf dem interdisziplinaren Gebiet zwischen Chemie, Biologie, Medizin und Materialwissenschaften nehmen organische Azide inzwischen einen wichtigen Raum ein. In diesem Aufsatz werden die Grundzuge der Azid-Chemie dargelegt und aktuelle Entwicklungen auf diesem Gebiet beleuchtet. Der Schwerpunkt liegt dabei auf Cycloadditionen (Huisgen-Reaktion), Aza-Ylidchemie und der Synthese von Heterocyclen. Weitere Reaktionen wie die Aza-Wittig-Reaktion, Sundberg-Umlagerung, Staudinger-Ligation, Boyer- und Boyer-Aube-Umlagerung, Curtius-Umlagerung, Schmidt-Umlagerung sowie die Hemetsberger-Umlagerung zeugen von der Vielfaltigkeit moderner Azid-Chemie.
307 citations