G
Giampietro Schiavo
Researcher at University College London
Publications - 311
Citations - 24565
Giampietro Schiavo is an academic researcher from University College London. The author has contributed to research in topics: Synaptic vesicle & Axoplasmic transport. The author has an hindex of 78, co-authored 288 publications receiving 22542 citations. Previous affiliations of Giampietro Schiavo include UCL Institute of Neurology & London Research Institute.
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Journal ArticleDOI
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
Giampietro Schiavo,Fabio Benfenati,Bernard Poulain,Ornella Rossetto,Patrizia Polverino de Laureto,Bibhuti R. DasGupta,Cesare Montecucco +6 more
TL;DR: The results indicate that tetanus and botulinum B neurotoxins block neurotransmitter release by cleaving synaptobrevin-2, a protein that, on the basis of the results, seems to play a key part in neurotransmitterRelease.
Journal ArticleDOI
Neurotoxins Affecting Neuroexocytosis
TL;DR: The mechanism of action of three groups of presynaptic neurotoxins that interfere directly with the process of neurotransmitter release is reviewed, whereas presynapses acting on ion channels are not dealt with here.
Journal ArticleDOI
Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport
Majid Hafezparast,Rainer Klocke,Christiana Ruhrberg,Andreas Marquardt,Azlina Ahmad-Annuar,Samantha Bowen,Giovanna Lalli,Abi S. Witherden,Holger Hummerich,Sharon E. Nicholson,P. Jeffrey Morgan,Ravi Oozageer,John V. Priestley,Sharon Averill,V.R. King,Simon T. Ball,Jo Peters,Takashi Toda,Ayumu Yamamoto,Yasushi Hiraoka,Martin Augustin,Dirk Korthaus,Sigrid Wattler,Philipp Wabnitz,Carmen Dickneite,Stefan Lampel,Florian Boehme,Gisela Peraus,Andreas Popp,Martina Rudelius,Juergen Schlegel,Helmut Fuchs,Martin Hrabé de Angelis,Giampietro Schiavo,David T. Shima,Andreas Russ,Gabriele Stumm,Joanne E. Martin,Elizabeth M. C. Fisher +38 more
TL;DR: It is shown that missense point mutations in the cytoplasmic dynein heavy chain result in progressive motor neuron degeneration in heterozygous mice, and in homozygotes this is accompanied by the formation of Lewy-like inclusion bodies, thus resembling key features of human pathology.
Journal ArticleDOI
Structure and function of tetanus and botulinum neurotoxins
TL;DR: Tetanus and botulinum neurotoxins form a new group of zinc-endopeptidases with characteristic sequence, mode of zinc coordination, mechanism of activation and target recognition, of great value in the unravelling of the mechanisms of exocytosis and endocytotic, as they are in the clinical treatment of dystonias.
Journal ArticleDOI
Rab5 and Rab7 Control Endocytic Sorting along the Axonal Retrograde Transport Pathway
Katrin Deinhardt,Sara Salinas,Carole Verastegui,Rose Watson,Daniel Worth,Sarah Hanrahan,Cecilia Bucci,Giampietro Schiavo +7 more
TL;DR: The data demonstrate that TeNT H(C) uses a retrograde transport pathway shared with p75(NTR), TrkB, and BDNF, which is strictly dependent on the activities of both Rab5 and Rab7, and therefore Rab7 plays an essential role in axonal retrogrades transport by controlling a vesicular compartment implicated in neurotrophin traffic.