Gianfranco Fiore

TL;DR: In this article, an experimental and computational approach to control the expression of a protein in a population of yeast cells is described. But the approach is limited to the control of a single protein fused to a fluorescent reporter, provided that an external molecule known to affect its promoter activity is available.

TL;DR: The MPC controller can track fast reference signals better than ZAD but with a higher actuation effort due to the large number of input switches it requires, and the PI controller's performance is comparable to that achieved by the MPC and the ZAD controllers only for the set-point regulation.

TL;DR: The effects of distributing the various functions required to build a control system across two populations are studied, the robustness and modularity of the strategy described are proved, and a computational proof-of-concept of its feasibility is provided.

TL;DR: This work implements a system that compares the concentration of two signal molecules, and tunes GFP expression proportionally to their relative abundance, performed via molecular titration between an orthogonal σ factor and its cognate anti-σ factor.

TL;DR: In this article, the authors study motor coordination in a group of individuals where participants are asked to visually coordinate an oscillatory hand motion, and show that the coordination level of the ensemble depends on group homogeneity, as well as on the pattern of visual couplings.