Gideon Koren

TL;DR: Both cocaine and nicotine may contribute to fetal growth restriction by interfering with the activity of amino acids transporters that are necessary to maintain the nutrient gradients associated with normal fetal growth.

TL;DR: The studies suggest that the alterations in the distribution volume of fentanyl in these children may largely depend upon the severity of the hemodynamic disturbance whereas TBC of the drug may depend on their age.

TL;DR: Excessive serum concentrations of digoxin may not necessarily reflect potentially toxic levels, and there was a good correlation between digoxin elimination T1/2 and serum creatine concentrations.

TL;DR: Some interesting avenues of research require further pursuit- including evidence of cytochrome P450 2D6 (CYP2D6) induction during pregnancy and its effect on the generation of the active opioid metabolites morphine, oxymorphone, O-desmethyltramadol, and hydromorphone following the administration of codeine, oxycodone, tramadol and hydrocodone respectively.

TL;DR: Machine learning of big data is a novel method to identify effective antihypertensive therapy and for repurposing medications already on the market for new indications and should be corroborated and affirmed by other methods.