G
Gilles Dujardin
Researcher at Centre national de la recherche scientifique
Publications - 47
Citations - 642
Gilles Dujardin is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Cycloaddition & Enantioselective synthesis. The author has an hindex of 14, co-authored 47 publications receiving 563 citations. Previous affiliations of Gilles Dujardin include University of Maine.
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Isoxazolidine: A Privileged Scaffold for Organic and Medicinal Chemistry
TL;DR: This review aims to be a comprehensive and general summary of the different isoxazolidine syntheses, their use as starting building blocks for the preparation of natural compounds, and their main biological activities.
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Lewis Acid Tuned Facial Stereodivergent HDA Reactions Using β-Substituted N-Vinyloxazolidinones
Frederic Gohier,Keltoum Bouhadjera,Djibril Faye,Catherine Gaulon,Vincent Maisonneuve,Gilles Dujardin,Robert Dhal +6 more
TL;DR: The [4 + 2] acido-catalyzed heterocycloaddition between new beta-substituted N-vinyl-1,3-oxazolidin-2-ones and beta,gamma-unsaturated alpha-ketoesters afforded heteroadducts with high levels of endo and facial selectivities.
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Access to α-Substituted Amino Acid Derivatives via 1,3-Dipolar Cycloaddition of α-Amino Ester Derived Nitrones
Thanh Binh Nguyen,Alice Beauseigneur,Arnaud Martel,Robert Dhal,Mathieu Y. Laurent,Gilles Dujardin +5 more
TL;DR: From the adducts derived from vinyl ethers, a three-step access to highly functionalized alpha-substituted amino acid derivatives is described, which creates a tetrafunctionalized stereogenic quaternary center.
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Novel Use of N-Benzoyl-N,O-acetals as N-Acylimine Equivalents in Asymmetric Heterocycloaddition: An Extended Enantioselective Pathway to β-Benzamido Aldehydes
TL;DR: For the first time, easily available N-(alpha-methoxyalkyl)amides were successfully used as synthetic equivalents of N-acylimines in an asymmetric heterocycloaddition process and new beta-aryl- and beta-alkyl-substituted benzamido aldehydes were obtained in good overall yields with high enantioselectivities.
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First Asymmetric Synthesis of a 6-Alkoxy-5,6-dihydro-1,3-oxazine: A Promising Enantioselective Route to β-Amido Aldehydes
TL;DR: The 1,3-oxazine route to enantiopure beta-amido aldehydes was investigated and high diastereocontrols were observed when using Yb(fod)3-catalyzed or SnCl4-mediated conditions, thus leading after quantitative hydrolysis to (R)-N-benzoyl-3-phenylpropanal with >98% ee.