G
Gin C. Hsieh
Researcher at Abbott Laboratories
Publications - 59
Citations - 3279
Gin C. Hsieh is an academic researcher from Abbott Laboratories. The author has contributed to research in topics: Agonist & Receptor. The author has an hindex of 32, co-authored 59 publications receiving 3103 citations.
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Journal ArticleDOI
A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
Prisca Honore,Diana L. Donnelly-Roberts,Marian T. Namovic,Gin C. Hsieh,Chang Z. Zhu,Joe Mikusa,Gricelda Hernandez,Chengmin Zhong,Donna M. Gauvin,Prasant Chandran,Richard R. Harris,Arturo Perez Medrano,William A. Carroll,Kennan C. Marsh,James P. Sullivan,Connie R. Faltynek,Michael F. Jarvis +16 more
TL;DR: It is demonstrated that selective blockade of P2X7 receptors in vivo produces significant antinociception in animal models of neuropathic and inflammatory pain.
Journal ArticleDOI
Localization of histamine H4 receptors in the central nervous system of human and rat.
Marina I. Strakhova,Arthur L. Nikkel,Arlene M. Manelli,Gin C. Hsieh,Timothy A. Esbenshade,Jorge D. Brioni,Robert S. Bitner +6 more
TL;DR: In this article, the authors present the results of experiments that were conducted in order to elucidate H4 receptor expression and localization in the brain, spinal cord, and dorsal root ganglia (DRG).
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In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models.
B B Yao,Gin C. Hsieh,Jennifer M. Frost,Y Fan,Tiffany Runyan Garrison,Anthony V. Daza,George K. Grayson,Chang Z. Zhu,Madhavi Pai,Prasant Chandran,Anita K. Salyers,Erica J. Wensink,Prisca Honore,James P. Sullivan,Michael J. Dart,Michael Meyer +15 more
TL;DR: In vitro and in vivo pharmacological properties of A‐796260, a novel CB2 agonist, are described, which shows analgesic effects are μ‐opioid receptor‐dependent.
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Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity
Jennifer M. Frost,Michael J. Dart,Karin R. Tietje,Tiffany Runyan Garrison,George K. Grayson,Anthony V. Daza,Odile F. El-Kouhen,B B Yao,Gin C. Hsieh,Madhavi Pai,Chang Z. Zhu,Prasant Chandran,Michael Meyer +12 more
TL;DR: N1 aromatic side chains also afforded several high affinity CB(2) receptor agonists but were generally less potent in an in vitro CB( 2) functional assay than were nonaromatic side chain analogues.
Journal ArticleDOI
Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
Gin C. Hsieh,Madhavi Pai,Prasant Chandran,Bradley A. Hooker,Chang Z. Zhu,Anita K. Salyers,Erica J. Wensink,Cenchen Zhan,William A. Carroll,Michael J. Dart,B B Yao,Prisca Honore,Michael Meyer +12 more
TL;DR: The present study elucidated the CB2 receptor expression in ‘pain relevant’ tissues and the potential sites of action of CB2 agonism in rats to elucidate the mechanisms underlying CB2‐mediated analgesic effects.