G
Gioacchino Natoli
Researcher at European Institute of Oncology
Publications - 162
Citations - 28139
Gioacchino Natoli is an academic researcher from European Institute of Oncology. The author has contributed to research in topics: Transcription factor & Regulation of gene expression. The author has an hindex of 64, co-authored 153 publications receiving 24531 citations. Previous affiliations of Gioacchino Natoli include University of Milan & Policlinico Umberto I.
Papers
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Journal ArticleDOI
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray,Judith E. Allen,Subhra K. Biswas,Edward A. Fisher,Derek W. Gilroy,Sergij Goerdt,Siamon Gordon,John A. Hamilton,Lionel B. Ivashkiv,Toby Lawrence,Massimo Locati,Alberto Mantovani,Fernando O. Martinez,Jean-Louis Mege,David M. Mosser,Gioacchino Natoli,Jeroen P. J. Saeij,Joachim L. Schultze,Kari Ann Shirey,Antonio Sica,Jill Suttles,Irina A. Udalova,Jo A. Van Ginderachter,Stefanie N. Vogel,Thomas A. Wynn +24 more
TL;DR: A set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation are described with the goal of unifying experimental standards for diverse experimental scenarios.
Journal ArticleDOI
Transcriptional regulation of macrophage polarization: enabling diversity with identity.
Toby Lawrence,Gioacchino Natoli +1 more
TL;DR: This Review summarizes the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and disease and describes a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines Macrophage identity.
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Trained immunity: A program of innate immune memory in health and disease
Mihai G. Netea,Leo A. B. Joosten,Eicke Latz,Kingston H. G. Mills,Gioacchino Natoli,Hendrik G. Stunnenberg,Luke A. J. O'Neill,Ramnik J. Xavier +7 more
TL;DR: Proof-of-principle experimental studies support the hypothesis that trained immunity is one of the main immunological processes that mediate the nonspecific protective effects against infections induced by vaccines, such as bacillus Calmette-Guérin or measles vaccination.
Journal ArticleDOI
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
Antonio Rossi,Pankaj Kapahi,Gioacchino Natoli,Takayuki Takahashi,Yi Chen,Michael Karin,M. Gabriella Santoro +6 more
TL;DR: A novel mechanism of anti-inflammatory activity which is based on the direct inhibition and modification of the IKKβ subunit of IKK is demonstrated, which explains how cyclopentenone prostaglandins function and can be used to improve the utility of COX2 inhibitors.
Journal ArticleDOI
IKK-γ is an essential regulatory subunit of the IκB kinase complex
TL;DR: In this paper, a large, cytokine-responsive IkappaB kinase (IKK) complex has been purified and the genes encoding two of its subunits have been cloned.