G
Giorgio Minotti
Researcher at Università Campus Bio-Medico
Publications - 145
Citations - 9871
Giorgio Minotti is an academic researcher from Università Campus Bio-Medico. The author has contributed to research in topics: Cardiotoxicity & Anthracycline. The author has an hindex of 40, co-authored 136 publications receiving 9099 citations. Previous affiliations of Giorgio Minotti include National Institutes of Health & University of Chieti-Pescara.
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Journal ArticleDOI
Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity
TL;DR: An overview of issues confirms that anthracyclines remain “evergreen” drugs with broad clinical indications but have still an improvable therapeutic index.
Journal ArticleDOI
The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.
Giorgio Minotti,Steven D. Aust +1 more
TL;DR: Using Fe2+, H2O2, and phospholipid liposomes as a model system, it is found that lipid peroxidation, as assessed by malondialdehyde formation, is not initiated by the hydroxyl radical, but rather requires Fe3+ and Fe2+.
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Anthracycline Cardiotoxicity: From Bench to Bedside
Luca Gianni,Eugene H. Herman,Steven E. Lipshultz,Giorgio Minotti,Narine Sarvazyan,Douglas B. Sawyer +5 more
TL;DR: The First International Workshop on Anthracycline Cardiotoxicity, held in fall 2006, focused on the state-of-the-art knowledge and discussed the research needed to address the cardiotoxicity of these drugs and is incorporated into the framework of a broader review of preclinical and clinical issues.
Journal ArticleDOI
The role of iron in the initiation of lipid peroxidation.
Giorgio Minotti,Steven D. Aust +1 more
TL;DR: Evidence is presented that lipid peroxidation requires both Fe3+ and Fe2+, perhaps with oxygen to form a Fe3-dioxygen-Fe2+ complex.
Journal ArticleDOI
An investigation into thee mechanism of citrateFE2+-dependent lipid peroxidation
Giorgio Minotti,Steven D. Aust +1 more
TL;DR: Chelation by citrate was found to promote the autoxidation of Fe2+, measured as the disappearance of 1,10-phenanthroline-chelatable Fe2+, and evidence is presented to suggest that the superoxide and the hydrogen peroxide can either stimulate or inhibit lipid peroxidation by affecting the yield of citrate-Fe3+.