G
Giovanna Chiorino
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 128
Citations - 5660
Giovanna Chiorino is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 41, co-authored 110 publications receiving 4852 citations. Previous affiliations of Giovanna Chiorino include University of Pau and Pays de l'Adour & Claude Bernard University Lyon 1.
Papers
More filters
Journal ArticleDOI
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
Bach Cuc Nguyen,Karine Lefort,Anna Mandinova,Dario Antonini,Vikram Devgan,Giusy Della Gatta,Maranke I. Koster,Zhuo Zhang,Jian Wang,Alice Tommasi di Vignano,Jan Kitajewski,Giovanna Chiorino,Dennis R. Roop,Caterina Missero,G. Paolo Dotto +14 more
TL;DR: A complex cross-talk between Notch and p63 is involved in the balance between keratinocyte self-renewal and differentiation, with the Hes-1 gene as one of its direct negative targets.
Journal ArticleDOI
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases
Karine Lefort,Anna Mandinova,Paola Ostano,Vihren N. Kolev,Valérie Calpini,Ingrid Kolfschoten,Vikram Devgan,Jocelyn Lieb,Wassim Raffoul,Daniel Hohl,Victor A. Neel,Jonathan Garlick,Giovanna Chiorino,G. Paolo Dotto +13 more
TL;DR: The Notch1 gene is a p53 target with a role in human tumor suppression through negative regulation of Rho effectors, with expression of this gene being under p53 control in keratinocyte cancer cell lines and tumors.
Journal ArticleDOI
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
Erica Salvati,Carlo Leonetti,Angela Maria Rizzo,Marco Scarsella,Marcella Mottolese,Rossella Galati,Isabella Sperduti,Malcolm F. G. Stevens,Maurizio D'Incalci,Maria A. Blasco,Giovanna Chiorino,Serge Bauwens,Béatrice Horard,Eric Gilson,Antonella Stoppacciaro,Gabriella Zupi,Annamaria Biroccio +16 more
TL;DR: It is shown that RHPS4 triggers a rapid and potent DNA damage response at telomeres in human transformed fibroblasts and melanoma cells, and the key role of telomere-protective factors TRF2 and POT1 in response to this anti-telomere strategy is revealed.
Journal ArticleDOI
Current understanding of the thrombospondin-1 interactome.
TL;DR: Current knowledge of the TSP-1 interactome map is illustrated, based on information from protein interaction databases and the literature, to lay the basis for the rational design of T SP-1-based therapeutic approaches.
Journal ArticleDOI
High Commitment of Embryonic Keratinocytes to Terminal Differentiation through a Notch1-caspase 3 Regulatory Mechanism
Ryuhei Okuyama,Bach Cuc Nguyen,Claudio Talora,Eisaku Ogawa,Alice Tommasi di Vignano,Maria Lioumi,Giovanna Chiorino,Hachiro Tagami,Minna Woo,G. Paolo Dotto,G. Paolo Dotto +10 more
TL;DR: It is reported here that pure keratinocyte populations from E15.5 mouse embryos commit irreversibly to differentiation much earlier than newborn cells, suggesting a Notch1-caspase 3 regulatory mechanism underlies the intrinsically high commitment of embryonic keratinocytes to terminal differentiation.