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Giovanni Diana

Bio: Giovanni Diana is an academic researcher from King's College London. The author has contributed to research in topics: Electroweak interaction & Perturbative QCD. The author has an hindex of 12, co-authored 31 publications receiving 755 citations. Previous affiliations of Giovanni Diana include Pasteur Institute & University of Luxembourg.

Papers
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Journal ArticleDOI
TL;DR: A detailed picture of the BM vasculature in acute myeloid leukemia using intravital two-photon microscopy is provided and inhibition of NO production reduced vascular permeability, preserved normal hematopoietic stem cell function, and improved treatment response in PDX.

165 citations

Journal ArticleDOI
TL;DR: The BLACKHAT library is used in conjunction with SHERPA and a recently developed algorithm for assembling primitive amplitudes into color-dressed amplitudes to adopt the cuts used by ATLAS in their study of multijet events in pp collisions at √s=7 TeV.
Abstract: We present the cross sections for production of up to four jets at the Large Hadron Collider, at next-to-leading order in the QCD coupling. We use the BlackHat library in conjunction with SHERPA and a recently developed algorithm for assembling primitive amplitudes into color-dressed amplitudes. We adopt the cuts used by ATLAS in their study of multijet events in $pp$ collisions at $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$. We include estimates of nonperturbative corrections and compare to ATLAS data. We store intermediate results in a framework that allows the inexpensive computation of additional results for different choices of scale or parton distributions.

117 citations

Journal ArticleDOI
TL;DR: This paper showed that the left-handed nature of the $W$ coupling, combined with valence quark domination at a $pp$ machine, leads to a large lefthanded polarization for both $W+$ and $W−$ bosons at large transverse momenta.
Abstract: The production of $W$ bosons in association with jets is an important background to new physics at the LHC. Events in which the $W$ carries large transverse momentum and decays leptonically lead to large missing energy and are of particular importance. We show that the left-handed nature of the $W$ coupling, combined with valence quark domination at a $pp$ machine, leads to a large left-handed polarization for both ${W}^{+}$ and ${W}^{\ensuremath{-}}$ bosons at large transverse momenta. The polarization fractions are very stable with respect to QCD corrections. The leptonic decay of the ${W}^{\ifmmode\pm\else\textpm\fi{}}$ bosons translates the common left-handed polarization into a strong asymmetry in transverse momentum distributions between positrons and electrons and between neutrinos and antineutrinos (missing transverse energy). Such asymmetries may provide an effective experimental handle on separating $W+\mathrm{\text{jets}}$ from top-quark production, which exhibits very little asymmetry due to C invariance, and from various types of new physics.

97 citations

Journal ArticleDOI
18 Nov 2019-eLife
TL;DR: The neuronal output of individual progenitor cells in the developing mouse neocortex is investigated using a combination of methods that together circumvent the biases and limitations of individual approaches to support a mechanism for cortical neurogenesis whose flexibility would make it capable to generate the diverse cytoarchitectures that characterize distinct neocortical areas.
Abstract: Recognizable by its deep outer folds in humans, the cerebral cortex is a region of the mammalian brain which handles complex processes such as conscious perception or decision-making. It is organized in several layers that contain different types of ‘excitatory’ neurons which can activate other cells. The various areas of the cortex have different characteristics as they contain various proportions of each kind of neurons. Stem cells are cells capable to divide and create various types of specialized cells. The excitatory neurons in the cortex are created during development by stem cells known as radial glial cells. These cells divide several times, giving rise to different types of neurons in sucessive divisions, presumably thanks to internal molecular clocks. In the cortex, it is generally assumed that an individual radial glial cell produces all the different types of excitatory neurons. However, studies have suggested that certain cells could be specialized in creating specific types of neurons. To explore this question, Llorca et al. used three complementary approaches to follow individual radial glial cells and track the neurons they created in mouse embryos. This helped to understand how groups of stem cells work together to build the cortex. The experiments revealed that radial glial cells differ more than anticipated in the number and the types of neurons they generate, and rarely produce all types of excitatory neurons. In other words, the output of individual radial glial cells is not always the same. The results by Llorca et al. suggest that as radial glial cells divide, they undergo a series of probabilistic decisions – that is, in each division the cells have a certain probability to generate a specific type of neuron. Consequently, the resulting lineages are rarely identical or contain all types of excitatory neurons, but collectively they generate the full diversity of excitatory neurons in the cortex. Ultimately, new insights into how excitatory neurons form and connect in the brain may be used to help understand psychiatric conditions where circuits in the cortex might be impaired, such as in autism spectrum disorders.

79 citations

Journal ArticleDOI
TL;DR: This work addresses the issue of minimizing the heat generated when erasing the information stored in an array of quantum dots in finite time and identifies the fundamental limitations and trade-offs involved.
Abstract: We address the issue of minimizing the heat generated when erasing the information stored in an array of quantum dots in finite time. We identify the fundamental limitations and trade-offs involved in this process and analyze how a feedback operation can help improve it.

72 citations


Cited by
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Journal ArticleDOI
TL;DR: MadGraph5 aMC@NLO as discussed by the authors is a computer program capable of handling all these computations, including parton-level fixed order, shower-matched, merged, in a unified framework whose defining features are flexibility, high level of parallelisation and human intervention limited to input physics quantities.
Abstract: We discuss the theoretical bases that underpin the automation of the computations of tree-level and next-to-leading order cross sections, of their matching to parton shower simulations, and of the merging of matched samples that differ by light-parton multiplicities. We present a computer program, MadGraph5 aMC@NLO, capable of handling all these computations — parton-level fixed order, shower-matched, merged — in a unified framework whose defining features are flexibility, high level of parallelisation, and human intervention limited to input physics quantities. We demonstrate the potential of the program by presenting selected phenomenological applications relevant to the LHC and to a 1-TeV e + e − collider. While next-to-leading order results are restricted to QCD corrections to SM processes in the first public version, we show that from the user viewpoint no changes have to be expected in the case of corrections due to any given renormalisable Lagrangian, and that the implementation of these are well under way.

6,509 citations

Journal ArticleDOI
TL;DR: Van Kampen as mentioned in this paper provides an extensive graduate-level introduction which is clear, cautious, interesting and readable, and could be expected to become an essential part of the library of every physical scientist concerned with problems involving fluctuations and stochastic processes.
Abstract: N G van Kampen 1981 Amsterdam: North-Holland xiv + 419 pp price Dfl 180 This is a book which, at a lower price, could be expected to become an essential part of the library of every physical scientist concerned with problems involving fluctuations and stochastic processes, as well as those who just enjoy a beautifully written book. It provides an extensive graduate-level introduction which is clear, cautious, interesting and readable.

3,647 citations

Book
01 Jan 2010

1,870 citations

Journal ArticleDOI
TL;DR: In this article, the authors present a theoretical framework for the thermodynamics of information based on stochastic thermodynamics and fluctuation theorems, review some recent experimental results, and present an overview of the state of the art in the field.
Abstract: By its very nature, the second law of thermodynamics is probabilistic, in that its formulation requires a probabilistic description of the state of a system. This raises questions about the objectivity of the second law: does it depend, for example, on what we know about the system? For over a century, much effort has been devoted to incorporating information into thermodynamics and assessing the entropic and energetic costs of manipulating information. More recently, this historically theoretical pursuit has become relevant in practical situations where information is manipulated at small scales, such as in molecular and cell biology, artificial nano-devices or quantum computation. Here we give an introduction to a novel theoretical framework for the thermodynamics of information based on stochastic thermodynamics and fluctuation theorems, review some recent experimental results, and present an overview of the state of the art in the field. The task of integrating information into the framework of thermodynamics dates back to Maxwell and his infamous demon. Recent advances have made these ideas rigorous—and brought them into the laboratory.

879 citations