Giovanni Lugli

TL;DR: The findings warrant replication and follow-up with a larger cohort of patients and controls who have been carefully characterized in terms of cognitive and imaging data, other biomarkers and risk factors, and who are sampled repeatedly over time.

TL;DR: Overall miRNA expression was significantly and globally down-regulated in prefrontal cortex of depressed suicide subjects, and a set of 29 miRNAs showed a high degree of co-regulation across individuals in the depressed suicide group.

TL;DR: The findings support a model whereby acute neuronal stimulation at excitatory synapses increases intracellular calcium, which activates calpain, which liberates dicer and eIF2c bound to PSDs, which supports the hypothesis that dicer could be involved in synaptic plasticity.

TL;DR: Findings support the proposal that microRNAs are formed, at least in part, via processing of microRNA precursors locally within dendritic spines via synaptic stimulation in proximity to the synapse.

TL;DR: There was a significant inverse correlation between the fold-change of a given miRNA seen in schizophrenia and its synaptic enrichment ratio observed in controls, suggesting some deficit in miRNA biogenesis, transport, processing or turnover in schizophrenia that is selective for the synaptic compartment.