Author
Gira P. Mankad
Bio: Gira P. Mankad is an academic researcher. The author has contributed to research in topics: Thalassemia & Blood transfusion. The author has co-authored 2 publications.
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TL;DR: In this study 115 patients were screened for HBsAg, HCV and HIV antigen markers to check safety of cryoprecipitate they receive and only one person was found to beHBsAg positive and one personWas HCV positive; no seropositivity for HIV was found.
Abstract: Hemophilia is an inherited bleeding disorder. In majority patients either clotting factor vii is in low level (Hemophilia A) or clotting factor ix is deficient (Hemophilia B). For the management of hemophilia, a patient needs to be transfused purified factor preparation or cryoprecipitated plasma. This makes patient susceptible to transfusion transmitted infections. In our study 115 patients were screened for HBsAg, HCV and HIV antigen markers to check safety of cryoprecipitate they receive. Only one person was found to be HBsAg positive and one person was HCV positive. No seropositivity for HIV was found. Advance procedure for virus inactivation and strictly mainting a pool of selected donors for plasma can be major causes for such rate of viral infection in hemophilic patients.
TL;DR: A very low hemoglobin level with very high SGPT level along with sleenomegaly is suggestive of poor prognosis in patients with thalassaemia.
Abstract: Absract: Thalassemia describes a group of inherited disorders characterized by reduced amount of hemoglobin, the oxygen-carrying protein inside the red blood cells. Various haematological and serological parameters were studied in a cohort of thalasaemic patients coming for routine blood transfusion regime in a government run children hospital of Rajkot. Due to poor socio-economic condition, none of the patients were taking chelation therapy needed for better management of thalassaemia. To get insight into effect of multiple blood transfusions on these patients, age, spleen status, distribution of blood group, hemoglobin level and other hematological indices and serolological parameter like SGPT related to iron overburden was studied. A very low hemoglobin level with very high SGPT level along with sleenomegaly is suggestive of poor prognosis in these patients.