Giuseppe Bruno

TL;DR: Quarantine induces a rapid increase of BPSD in approximately 60% of patients and stress-related symptoms in two-thirds of caregivers and were associated with increased patients’ neuropsychiatric burden (p<0.0001); health services need to plan a post-pandemic strategy.

TL;DR: Five derivatives of 5-arylidene-2-imino-4-thiazolidinones exhibited significant activity levels in models of acute inflammation such as carrageenan-induced paw and pleurisy edema in rats, and the ability of such a new class of anti-inflammatory agents to inhibit COX isoforms was assessed in murine monocyte/macrophage J774 cell line assay.

TL;DR: It was found that the substitution pattern on the 5-benzylidene moiety markedly influenced the activity of N-unsubstituted 2,4-thiazolidinediones 2, compounds with substituents at the meta position being generally more effective than the para-subst ituted ones; however, this SAR was not evidenced in acetates 3 and acids 4.

TL;DR: In this paper, the synthesis, structure, and spectroscopic and magnetic properties of three 2,2'-bipyrimidine (C 8 H 6 N 4, bpm)-containing copper(II) complexes of formula [Cu 2 (bpm)(NCO) 4 ] n (1), (Cu(bpm) 2 ] n(2) and [Cu 1 n 2, n(3) n (3) are reported.

TL;DR: Whether the clinical conditions of patients with dementia and cognitive disturbances have changed during the COVID-19 pandemic was explored to gain insights on how to rearrange the provision of care in the postemergency phase.