Giuseppe Caruso

TL;DR: It is demonstrated that molecular analysis of cytological specimens is feasible and that its results in combination with cytology improves the diagnostic performance of traditional cytology.

TL;DR: Robust biomarker–drug codevelopment pipelines are expected to enrich large-scale clinical trials testing new-generation compounds active, directly or indirectly, on neuroinflammatory targets and displaying putative disease-modifying effects: novel NSAIDs, AL002 (anti-TREM2 antibody), anti-Aβ protofibrils (BAN2401), and AL003 ( anti-CD33 antibody).

TL;DR: FNMTC displays the features of clinical 'anticipation' with the second generation acquiring the disease at an earlier age and having more advanced disease at presentation, compared with the first generation.

TL;DR: The TGF‐&bgr;1 signaling pathway is proposed as a common pharmacological target in depression and AD, and the potential rescue of TGF-1 signaling by antidepressants as a way to prevent the transition from depression to AD is discussed.

TL;DR: Data suggest hat sex steroids influence kainate‐induced seizures in a sex‐dependent manner and that the effects of the antiestrogen CC are dose dependent, which should be taken into account in view of a possible use of CC and MPA in hormonal therapy for seizure disorders.