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Showing papers by "Giuseppe Mancia published in 1968"


Journal ArticleDOI
21 Dec 1968-Nature
TL;DR: The “preparatory pattern” hypothesis, suggested recently that animals such as the cat and dog, when warned of an impending emotional or exertional task, anticipate the task with centrally induced cardiovascular changes similar to those that take place during the emotion or exertion itself, is suggested.
Abstract: IT has been suggested recently that animals such as the cat and dog, when warned of an impending emotional or exertional task, anticipate the task with centrally induced cardiovascular changes similar to those that take place during the emotion or exertion itself1,2. Particular emphasis has been placed on muscle vasodilatation, preparatory to and independent of muscle contraction, mediated through sympathetic fibres supposed to be cholinergic, because the vasodilatation can be abolished by atropine1,3. Most of the data on which the “preparatory pattern” hypothesis is based, however, have been obtained by electrical stimulation of certain regions in the hypothalamus or subthalamus, from which are evoked either cardiac changes similar to those during exercise but without concomitant muscle activity2 or cardiovascular changes as well as manifestations of defence behaviour1,4. It should be realized, however, that the most quoted experiment on unanaesthetized, naturally behaving animals that may be relevant to this hypothesis, is that by Abrahams et al.5 which showed an increase in muscle venous temperature, blocked by atropine, when “alerting” was induced by various sensory stimuli. The evidence it provides, however, rests on unverified assumptions that the venous temperature increase accurately reflected muscle vasodilatation, that there was no muscle activity which could have provided a metabolic vasodilatation, and that the behaviour was one preparatory to exertion or emotion.

37 citations


Journal ArticleDOI
TL;DR: Comparison of blood pressure and heart rate changes in synchronized and desynchronized sleep before and after various kinds of heart denervations has shown that the blood pressure fall occurring in sleep is independent of any nervous influence exerted on the heart.
Abstract: Comparison of blood pressure and heart rate changes in synchronized and desynchronized sleep before and after various kinds of heart denervations has shown that the blood pressure fall occurring in sleep is independent of any nervous influence exerted on the heart. Bradycardia is mostly due to increased vagal activity.

35 citations


Journal ArticleDOI
TL;DR: Durante il comportamento di lotta del gatto libero non anestetizzato si osserva tachicardia e aumento della gettata cardiaca; the pressione arteriosa e the conduttanza periferica totale variano relativamente poco.
Abstract: Durante il comportamento di lotta del gatto libero non anestetizzato si osserva tachicardia e aumento della gettata cardiaca; la pressione arteriosa e la conduttanza periferica totale variano relativamente poco Si ha una marcata vasocostrizione mesenterica, mentre il letto iliaco subisce modificazioni di senso opposto a seconda dell'attivita motoria dell'arto posteriore In assenza di movimento si ha una vasocostrizione, che interessa non solo il letto cutaneo ma anche quello muscolare; questa vasocostrizione viene invece soffocata da una cospicua vasodilatazione, d'evidente origine metabolica, ogni qual volta vi sia attivita muscolare locale

2 citations