Giuseppe Mancia

TL;DR: In this article, the authors examined whether benefits and risks of intensified antihypertensive therapy in patients with diabetes mellitus are influenced by either baseline BP or cardiovascular disease (CVD) risk, and found that the effects of randomized treatment on discontinuation of treatment because of cough or hypotension/dizziness were also statistically consistent across subgroups defined by baseline BP and CVD risk.

TL;DR: Compared with other antihypertensive agents, beta-blockers appear to be substantially less protective against stroke and overall mortality, but they exhibit a substantial risk-reducing ability for all events when prescribed to lower BP in patients with modest or more clear BP elevations, and therefore can be used as additional agents in hypertensive patients.

TL;DR: It is suggested to limit the clinical use of ambulatory blood pressure recording only to those expert centres able to guarantee high quality tracings and an appropriate interpretation of the results, and to restrict its application to carefully selected cases.

TL;DR: The study shows that SUA is a predictor of long-term echocardiographic changes from normal LVMI to LVH in a community sample, and life-style and pharmacologic measures aimed to reduce SUA levels may concur to preventing LVH development in the general population.

TL;DR: Arterial stiffness has the potential to be an important therapeutic target in the management of isolated systolic hypertension and the development of new treatments addressing neurohormonal alterations central to vascular ageing is important.