Giuseppe Rotilio

TL;DR: After consideration of the question of superoxide toxicity and superoxide pathology, several areas in which SOD has been investigated or used as a tool in a biochemical, pharmacological, or clinical context are discussed.

TL;DR: Reactions of H( 2)O(2) with superoxide dismutase were studied by e.p.r. (electron paramagnetic resonance) spectroscopy and other methods and it is suggested that this histidine is close to the metal in the native enzyme and essential for its enzymic activity.

TL;DR: Recent knowledge on the role played by several redox modulators in inducing signalling events that finally regulate cell cycle progression is summarised.

TL;DR: Evidence indicates that extrusion of reduced glutathione precedes and is responsible for the irreversible morphofunctional changes of apoptosis, probably by altering the intracellular redox state without intervention of reactive oxygen species, thus giving a rationale for the development of redox‐dependent apoptosis under anaerobic conditions.

TL;DR: Pre-steady-state rates of reduction and reoxidation of copper in the enzyme are consistent with these processes being rate-limiting in enzyme turnover, and it is suggested that the results may be best interpreted in terms of an allosteric type of mechanism, with two initially indistinguishable copper atoms in the enzymes.