G
Giuseppe Trigiante
Researcher at Ludwig Institute for Cancer Research
Publications - 15
Citations - 2059
Giuseppe Trigiante is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 8 publications receiving 1939 citations.
Papers
More filters
Journal ArticleDOI
ASPP proteins specifically stimulate the apoptotic function of p53.
Yardena Samuels-Lev,Daniel J. O'Connor,Daniele Bergamaschi,Giuseppe Trigiante,Jung-Kuang Hsieh,Shan Zhong,Isabelle Campargue,Louie Naumovski,Tim Crook,Xin Lu +9 more
TL;DR: The expression of ASPP is frequently downregulated in human breast carcinomas expressing wild-type p53 but not mutant p53, therefore, ASPP regulate the tumor suppression function of p53 in vivo.
Journal ArticleDOI
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.
Daniele Bergamaschi,Milena Gasco,Louise Hiller,Alexandra Sullivan,Nelofer Syed,Giuseppe Trigiante,Isik G. Yulug,Marco Merlano,Gianmauro Numico,Alberto Comino,Marlene Attard,Olivier Reelfs,Barry A. Gusterson,Alexandra K. Bell,Victoria J. Heath,Mahvash Tavassoli,Paul J. Farrell,Paul R. Smith,Xin Lu,Tim Crook +19 more
TL;DR: Polymorphism in p53 may influence individual responsiveness to cancer therapy, and clinical response following cisplatin-based chemo-radiotherapy for advanced head and neck cancer is influenced by this polymorphism, cancers expressing 72R mutants having lower response rates than those expressing 72P mutants.
Journal ArticleDOI
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
Daniele Bergamaschi,Yardena Samuels,Nigel J. O'Neil,Giuseppe Trigiante,Tim Crook,Jung-Kuang Hsieh,Daniel J. O'Connor,Shan Zhong,Isabelle Campargue,Matthew L. Tomlinson,Patricia E. Kuwabara,Xin Lu +11 more
TL;DR: iASPP is an evolutionarily conserved inhibitor of p53; inhibition of iASPP by RNA-mediated interference or antisense RNA in C. elegans or human cells, respectively, induces p53-dependent apoptosis and could provide an important new strategy for treating tumors expressing wild-type p53.
Journal ArticleDOI
Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo.
Alexandra Sullivan,Nelofer Syed,Milena Gasco,Daniele Bergamaschi,Giuseppe Trigiante,Marlene Attard,Louise Hiller,Paul J. Farrell,Paul R. Smith,Xin Lu,Tim Crook +10 more
TL;DR: It is demonstrated that the in vitro response of cells exposed to anticancer agents is strongly influenced by this SNP in wild-type p53, and that the outcome of chemo-radiotherapy of squamous carcinomas is more favourable in cancers retaining a wild- type 72R allele.
Journal ArticleDOI
ASPP [corrected] and cancer.
Giuseppe Trigiante,Xin Lu +1 more
TL;DR: The identification of a new family of proteins, known as ASPPs, has led to the discovery of a novel mechanism that selectively regulates the apoptotic function, but not the cell-cycle-arrest function, of p53 and gives an insight into how p53 responds to different stress signals.