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Giusy Tornillo
Researcher at Cardiff University
Publications - 32
Citations - 629
Giusy Tornillo is an academic researcher from Cardiff University. The author has contributed to research in topics: Stem cell & Progenitor cell. The author has an hindex of 14, co-authored 29 publications receiving 507 citations. Previous affiliations of Giusy Tornillo include University of Turin.
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Book ChapterDOI
Integrins and Signal Transduction
Sara Cabodi,Paola Di Stefano,Maria del Pilar Camacho Leal,Agata Tinnirello,Brigitte Bisaro,Virginia Morello,Laura Damiano,Simona Aramu,Daniele Repetto,Giusy Tornillo,Paola Defilippi +10 more
TL;DR: Recent experimental and conceptual advances in integrin signaling are highlighted with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.
Journal ArticleDOI
p130Cas is an essential transducer element in ErbB2 transformation
Sara Cabodi,Agata Tinnirello,Brigitte Bisaro,Giusy Tornillo,Maria del Pilar Camacho-Leal,Guido Forni,Rodica Cojoca,Manuela Iezzi,Augusto Amici,Maura Montani,Alessandra Eva,Paola Di Stefano,Senthil K. Muthuswamy,Guido Tarone,Emilia Turco,Paola Defilippi +15 more
TL;DR: It is demonstrated that p130Cas is an essential transducer element in ErbB2 transformation and highlighted its potential use as a novel therapeutic target in ErBB2 positive human breast cancers.
Journal ArticleDOI
Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia
Juan Bautista Menendez-Gonzalez,Milica Vukovic,Ali Abdelfattah,Lubaid Saleh,Alhomidi Almotiri,Leigh-anne Thomas,Aloña Agirre-Lizaso,Aleksandra Azevedo,Ana Catarina Menezes,Giusy Tornillo,Sarah Edkins,Kay Kong,Peter Giles,Fernando Anjos-Afonso,Alex Tonks,Ashleigh S. Boyd,Kamil R. Kranc,Neil P. Rodrigues +17 more
TL;DR: GATA2 acts as a critical regulator of normal and leukemic stem cells and mediates transcriptional networks that may be exploited therapeutically to target key facets of LSC behavior in AML.
Journal ArticleDOI
Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.
Giusy Tornillo,Catherine Knowlson,Howard Kendrick,Joe Cooke,Hasan Mirza,Iskander Aurrekoetxea-Rodríguez,Maria dM Vivanco,Niamh E. Buckley,Annita Grigoriadis,Matthew J. Smalley +9 more
TL;DR: It is demonstrated LYN is a downstream effector of c-KIT in normal mammary cells and protective of apoptosis upon genotoxic stress and dual mechanisms—uncoupling from upstream signals and splice isoform ratios—drive the activity of LYN in aggressive breast cancers.
Journal ArticleDOI
p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis.
Maria del Pilar Camacho Leal,Marianna Sciortino,Giusy Tornillo,Shana Colombo,Paola Defilippi,Sara Cabodi +5 more
TL;DR: More recent data on the contribution of p130Cas/BCAR1 in the regulation of tissue homeostasis and its potential implications in pathological conditions are discussed.