G
Glen S. Markowitz
Researcher at Columbia University
Publications - 220
Citations - 17297
Glen S. Markowitz is an academic researcher from Columbia University. The author has contributed to research in topics: Kidney disease & Glomerulonephritis. The author has an hindex of 66, co-authored 213 publications receiving 14801 citations. Previous affiliations of Glen S. Markowitz include Albert Einstein College of Medicine & Columbia University Medical Center.
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Journal ArticleDOI
Obesity-related glomerulopathy: an emerging epidemic.
TL;DR: ORG is distinct from idiopathic FSGS, with a lower incidence of nephrotic syndrome, more indolent course, consistent presence of glomerulomegaly, and milder foot process fusion.
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RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy.
Thoralf Wendt,Nozomu Tanji,Jiancheng Guo,Thomas Kislinger,Wu Qu,Yan Lu,Loredana G. Bucciarelli,Ling Ling Rong,Bernhard Moser,Glen S. Markowitz,Gunther Stein,Angelika Bierhaus,Birgit Liliensiek,Bernd Arnold,Peter P. Nawroth,David M. Stern,Vivette D. D'Agati,Ann Marie Schmidt +17 more
TL;DR: It is proposed that activation of RAGE contributes to expression of VEGF and enhanced attraction/activation of inflammatory cells in the diabetic glomerulus, thereby setting the stage for mesangial activation and TGF-beta production; processes which converge to cause albuminuria and glomerulosclerosis.
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Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease
Guanqing Wu,Vivette D. D'Agati,Yiqiang Cai,Glen S. Markowitz,Jong Hoon Park,David Reynolds,Yoshiko Maeda,Thanh C. Le,Harry Hou,Raju Kucherlapati,Winfried Edelmann,Stefan Somlo +11 more
TL;DR: Somatic loss of Pkd2 expression is both necessary and sufficient for renal cyst formation in ADPKD, suggesting that PKD2 occurs by a cellular recessive mechanism.
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Expression of Advanced Glycation End Products and Their Cellular Receptor RAGE in Diabetic Nephropathy and Nondiabetic Renal Disease
Nozomu Tanji,Glen S. Markowitz,Caifeng Fu,Thomas Kislinger,Akihiko Taguchi,Monika Pischetsrieder,David M. Stern,Ann Marie Schmidt,Vivette D. D'Agati +8 more
TL;DR: CML is a major AGE in renal basement membranes in diabetic nephropathy, and its accumulation involves upregulation of RAGE on podocytes, as assessed pathologically.
Journal ArticleDOI
Collapsing Focal Segmental Glomerulosclerosis Following Treatment with High-Dose Pamidronate
Glen S. Markowitz,Gerald B. Appel,Paul L. Fine,Andrew Z. Fenves,Nicholas R. Loon,Sundar Jagannath,Joseph A. Kuhn,Adam D. Dratch,Vivette D. D'Agati +8 more
TL;DR: The temporal association between pamidronate therapy and the development of renal insufficiency, the use of escalating doses that exceed recommended levels, and the distinctive pattern of glomerular andtubular injury strongly suggest a mechanism of drug-associated podocyte and tubular toxicity.